共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 缺氧缺血性脑损伤新生大鼠胎盘生长因子的表达及参附注射液的干预作用显示文摘目的通过分析胎盘生长因子(PLGF)在缺氧缺血性新生大鼠病侧大脑表达,探讨其改善脑缺血、促进脑内血管再生以及参附注射液对新生大鼠缺氧缺血性脑损伤(HIBD)的保护作用。方法新生7 d SD大鼠随机分为三组:假手术组(S)、生理盐水对照组(C)、参附治疗组(SF)。按观察时间可依次分为6 h、12 h、1 d、3 d、7 d五个亚组,每个亚组8只。用Rice法制备新生大鼠HIBD模型。SF组在缺氧缺血性脑损伤后即刻以腹腔注射注射,其剂量为10 ml/kg,每日1次,连续3日同一时间点用药。C组则按照相同的注射方式及注射剂量,给予生理盐水。S组未给予药物治疗。其后以RT-PCR和免疫组织化学的方法检测大鼠右侧大脑皮层PLGF的表达变化。结果 S组各个时间点PLGF均有表达,无明显差异(P>0.05);C组在6 h时PLGF表达量开始增加,于1 d时达到高峰期,明显高于S组(P<0.05);SF组在6 h前PLGF表达量开始增加,整体表达趋势类似于C组,3 d时下降趋势更明显,但各时间表达量明显高于S组及C组(P<0.05)。结论缺氧缺血性脑损伤后,PLGF表达量明显增加,参附注射液能促进PLGF大量表达,对缺氧缺血性脑损伤后的新生大鼠起到保护作用。 | 杨倩倩 王军 徐艳 刘文强 | 2017 | 中国儿童保健杂志2017，25，11： | 1 |
| 2 | Phenotype and target-based chemical biology investigations in cancers显示文摘Chemical biology has been attracting a lot of attention because of the key roles of chemical methods and techniques in helping to decipher and manipulate biological systems.Although chemical biology encompasses a broad field,this review will focus on chemical biology aimed at using exogenous chemical probes to interrogate,modify and manipulate biological processes,at the cellular and organismal levels,in a highly controlled and dynamic manner.In this area,many advances have been achieved for cancer biology and therapeutics,from target identification and validation based on active anticancer compounds(forward approaches)to discoveries of anticancer molecules based on some important targets including protein-protein interaction(reverse approaches).Herein we attempt to summarize some recent progresses mainly from China through applying chemical biology approaches to explore molecular mechanisms of carcinogenesis.Additionally,we also outline several new strategies for chemistry to probe cellular activities such as proximity-dependent labeling methods for identifying protein-protein interactions,genetically encoded sensors,and light activating or repressing gene expression system. | Guo-Qiang Chen Ying Xu Shao-Ming Shen Jian Zhang | 2019 | National Science Review2019，6，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员