| 1 | Hidden correlation of the effect mechanism on chronic gastritis treated with ginger-isolated moxibustion at different single acupoints显示文摘Objective: To observe the differences in the effects and mechanisms on chronic gastritis treated by ginger-isolated moxibustion at Zúsānlǐ(足三里ST 36) and Nèiguān(内关PC 6).Methods: A total of 60 eligible patients of chronic gastritis were randomized into two groups, a ST 36 group(ginger-isolated moxibustion at ST 36, 30 cases) and a PC 6 group(ginger-isolated moxibustion at PC 6, 30 cases). Before and after 6 treatments, the total variability of heart rate(TV) and the scores in Scale for gastrointestinal diseases of traditional Chinese medicine were determined and recorded. Using correlation analysis, the hidden correlation condition that affects the therapeutic outcomes was excavated from the data. With least square method, the gradient curve(K value) of TV in treatment was estimated and the correlation between the effect mechanism and autonomic nerve regulation was excavated.Results: ① In ST 36 group, the duration of sickness, severity of disease and the activity of autonomic nerve before treatment presented the underlying correlation with the therapeutic effects. In contrast, the hidden correlation in PC 6 group was not clear. ② In ST 36 group, the higher K value of TV in treatment was, the more significant the therapeutic effects were, but in PC group, K value was reversely related to the therapeutic effects.Conclusion: The therapeutic effects of ginger-isolated moxibustion at single acupoint are correlated with the duration and severity of sickness. The therapeutic effects in ST 36 group were improved by the modulation of autonomic nerve activity and the effects in PC 6 group were negatively correlated with autonomic nerve activity. It is deduced that the effect mechanisms are different on single acupoint for chronic gastritis between the two points. | 顾俊薇 杨旭明 李琪 顾沐恩 吴梦蝶 曹淑菲 李璟 | 2019 | World Journal of Acupuncture-Moxibustion2019，29，1： | 1 |
| 2 | Changes in Cold and Hot Syndromes and Gastrointestinal Bacterial Community Structure in Mice by Intervention with Food of Different Nature显示文摘Objective:To reveal the effect of foods with different natures on cold or hot syndrome and gastrointestinal bacterial community structure in mice.Methods:Forty-five 6-week-old male ICR Kunming mice of clean grade were divided into 5 groups,9 per group,including the control(CK),hot nature herb medicine(HM),Hong Qu glutinous rice wine(RW),tea rice wine(TW),and cold nature herb medicine(CM)groups.Distilled water or corresponding herbs were administered to mice(0.01 mL/g body weight)in the 5 groups by gastric infusion respectively,once daily for 28 d.Appearance,behavior,and serum biochemical indicators,including 5-hydroxytryptamine(5-HT),thyroid stimulating hormone(TSH),noradrenaline(NE),cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP),the hot nature index,as well as the gastrointestinal bacterial community structure were analyzed in all groups after treatment.Results:After supplementation for 28 d,CM and TW mice showed different degrees of cold syndrome,and HM and RW mice showed different degrees of hot syndrome.Compared with the HM and RW mice,the TSH,NE,cAMP levels and hot nature indices in the CM and TW mice were significantly decreased and 5-HT and cGMP levels were significantly increased(P<0.05).There was no obvious change in appearance or behavior in CK mice.Results of clustering analysis showed that the gastrointestinal bacterial community structures were highly similar in TW and CM mice as well as in RW and HM mice,and that they were from the same branch,respectively,when the distance was 0.02.The key microbes associated with cold syndrome were Lachnospiraceae uncultured,Lactococcus,etc.,and the key microbes associated with hot syndrome were S24-7 norank,Ruminococcaceae uncultured,etc.Conclusion:The interventions with different nature foods could change cold or hot syndrome in mice,leading to changes in gastrointestinal bacterial community structure. | LIANG Zhang-cheng LI Wei-xin HE Zhi-gang LIN Xiao-zi REN Xiang-yun LIN Xiao-jie | 2020 | Chinese Journal of Integrative Medicine2020，26，6： | 0 |
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