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| 1 | Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases显示文摘Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs. | Kevin Puertas-Neyra Ricardo Usategui-Martín Rosa MCoco Ivan Fernandez-Bueno | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 2 | 匍行性脉络膜炎的研究现状与进展显示文摘匍行性脉络膜炎(SC)是一种少见的双眼复发性、慢性进行性脉络膜炎症,主要侵犯脉络膜毛细血管层和视网膜色素上皮层。眼底典型表现为视盘周围灰黄色或灰白色多角形的盘状病灶。荧光素眼底血管造影、吲哚青绿血管造影、眼底自身荧光及光相干断层扫描等影像检查有助于不具有典型眼底改变的SC诊断,且可以评估病灶的活动性、进展、对药物治疗的反应以及监测可能发生的并发症。临床应主要与结核、病毒相关的多灶性SC进行鉴别诊断。SC病因不明,考虑其可能与自身免疫和感染相关。目前主要采用全身糖皮质激素和免疫抑制剂联合应用进行治疗;对于全身糖皮质激素禁忌者,可眼周、球内注射等局部运用糖皮质激素。及时有效的控制炎症能有效阻止SC患者的视力损伤、脉络膜新生血管以及脉络膜瘢痕的形成。 | 邹红 缪晚虹 | 2017 | 中华眼底病杂志2017，33，1： | 1 |
| 3 | 干细胞移植治疗视网膜和视神经变性疾病的现状和进展显示文摘不可逆性的视网膜和视神经退行性变会导致视功能严重损伤甚至致盲.近年来,干细胞移植治疗视网膜和视神经损伤的研究进展为组织的修复和再生带来了希望.干细胞既可以用于细胞替代治疗,也可以通过分泌细胞因子发挥神经营养保护作用.胚胎干细胞、间充质干细胞、诱导多能干细胞和M&252;ller细胞等各种来源的干细胞都极具发展前景,为眼科此类难治性疾病提供了丰富的资源. | 李晓虹 吴仁毅 | 2017 | 国际眼科纵览2017，41，3： | 0 |
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