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| 1 | miRNA对自然杀伤细胞生长发育及功能的调控作用显示文摘微小RNA(microRNAs,miRNAs)是长度为19~24 nt的内源性非编码小RNA。miRNA与自然杀伤(naturalkiller,NK)细胞的分化和功能密切相关,并参与传染病,肿瘤和其他病理过程的免疫调节。本文对近年来发现的miRNAs在NK细胞发育、分化和功能调控中的作用进行综述。 | 黄秋萍 袁欢 王宜林 黄庆生 李琦 | 2019 | 分子诊断与治疗杂志2019，11，1： | 18 |
| 2 | Warm up, cool down, and tearing apart in NK cell memory显示文摘“Memories warm you up from the inside.But they also tear you apart.”―Haruki Murakami,Kafka on the Shore.One of the characteristics of the human immune system,in addition to the recognition of nonself pathogens and the tolerance of self-antigens,is its memory response to previously encountered pathogens and the mounting of a stronger,faster secondary response against these same antigens.A long-held paradigm in immunologic study in vertebrates is that immune memory is restricted to the adaptive immune response via memory T and B cells,which possess two distinct features:specificity(recognizing pathogen antigen fragments through surface receptors)and longevity(proliferation and long-term survival after the first encounter).1–3 Unlike adaptive immunity,the innate immune system exhibits a rapid response against pathogens and transforming cells without a previous encounter,and this response depends on a series of default genes and proteins expressed on cell surfaces and in the cytoplasm that recognize the pathogen-associated molecular patterns(PAMPs)of pathogens.Therefore,it was surprising to find several models of pathogen infections in invertebrates,including insects,worms,and jawless fish,that lack fully developed adaptive immunity but possess the features of antigen specificity and longevity likely involving phagocytic cells that can“recall”prior infection with limited specificity.In fact,immune memory has recently been described in vertebrate myeloid lineages,4 in which epigenetic changes are proposed to occur in macrophages previously stimulated through pattern recognition receptors. | Lawrence Shih-Hsin Wu Jiu-Yao Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 3 |
| 3 | 穿孔素和颗粒酶B在急性期登革病毒患者体内的表达水平及调控机制初探显示文摘目的登革病毒(Dengue virus,DENV)感染引起的登革热和登革出血热已给世界带来极大危害,明确其感染引起的免疫病理损伤机制尤为关键。方法以DENV感染急性期患者样本为研究对象,抽取静脉血,利用密度梯度法提取外周单个核细胞(PBMCs),流式细胞术检测PBMCs各亚群表达穿孔素和颗粒酶B的水平,进而探讨DENV急性期患者T细胞亚群和NK细胞亚群免疫功能的差异。结果DENV患者CD8^+T细胞和NK细胞内穿孔素和颗粒酶B的表达水平发生显著上调,细胞脱颗粒水平也显著增加;同时表达穿孔素或颗粒酶B的NK细胞比例显著高于CD8^+T细胞。另外,本研究还发现三个重要miRNAs(miR-27a*、miR-30e和miR-378)在DENV患者体内的表达量明显降低,已有的研究表明其可能靶向调控穿孔素或/和颗粒酶B的表达。结论DENV感染可诱导CD8+T细胞和NK细胞发挥效应功能,并依赖穿孔素和颗粒酶途径杀伤被病毒感染的靶细胞;DENV患者体内PRF1和GrzB的表达很可能受到miR-27a*、miR-30e和miR-378的靶向调控。通过上述研究为阐明T细胞和NK细胞在DENV感染过程中所发挥的免疫效应功能提供更多的理论基础。 | 刘淑燕 张刘兵 刘爱玲 朱彩云 李东演 | 2019 | 中国热带医学2019，19，9： | 2 |
| 4 | 2017年广安市白纹伊蚊监测分析显示文摘目的了解广安市城区登革热媒介白纹伊蚊孳生环境数量及季节消长情况,指导科学开展登革热疫情防控。方法依据四川省2017年登革热媒介监测方案在城区不同方位检查室内外环境各种小型积水容器及蚊幼孳生情况,计算布雷图指数和容器指数。结果广安市白纹伊蚊孳生地多,2017年共调查1 404户,有各类小型积水容器4 810个。蚊虫密度高,5—8月白纹伊蚊布雷图指数(BI)均大于10,密度在6—7月达到高峰,布雷图指数(BI)分别为24. 39和38. 79,容器指数(CI)分别为7. 23和10. 64。结论广安市登革热媒介伊蚊密度较高,由输入病例引起本地流行和暴发的风险极高,应开展持续有效的蚊虫控制工作。 | 蔡运山 邓茂玲 王攀华 谢岸 洪嘉敏 | 2018 | 中华卫生杀虫药械2018，24，5： | 2 |
| 5 | 动物宿主microRNAs抗病毒作用机制研究进展显示文摘microRNAs(miRNAs)是一种长度为22nt的非编码RNA分子,能够结合mRNA,影响翻译效率,调控蛋白的表达。近来多项研究表明,动物宿主miRNAs通过多种机制抑制病毒的复制,如直接靶向病毒基因、干扰病毒复制所需因子、调节先天性免疫、调节细胞凋亡、调节细胞免疫,发挥抗病毒效应。本文归纳总结宿主miRNAs对病毒复制的调控机制,讨论miRNAs类抗病毒药物的应用情况,并展望该类药物的发展趋势。 | 樊晓旭 赵明 李林 吴晓东 王志亮 | 2017 | 病毒学报2017，33，5： | 2 |
| 6 | MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma显示文摘The important role of lncRNAs and miRNAs in directing immune responses has become increasingly clear.Recent evidence conforms that miRNAs and lncRNAs are involved in NK cell biology and diseases through RNAeprotein,RNAeRNA,or RNAeDNA interactions.In this view,we summarize the contribution of miRNAs and lncRNAs to NK cell lineage devel-opment,activation and function,highlight the biological significance of functional miRNAs or lncRNAs in NKTL and discuss the potential of these miRNAs and lncRNAs as innovative bio-markers/targets for NKTL early diagnosis,target treatment and prognostic evaluations. | Fengxia Gao Sirong He Aishun Jin | 2021 | Genes & Diseases2021，8，5： | 1 |
| 7 | Non-coding RNA: a key regulator of the pathogenicity and immunity of Flaviviridae viruses infection显示文摘Flaviviridae is a family of viruses that mainly spread through arthropod vectors,such as mosquitoes.Major members of the Flaviviridae family include dengue virus(DENV),yellow fever virus,Zika virus(ZIKV),West Nile virus and hepatitis C virus(HCV).As Flaviviridae viruses remain a major global public health threat,elucidation of the exact mechanisms of pathogenesis during infection is required for the successful control of these deadly viruses. | Zhiyi Zhang Lifang Jiang Gucheng Zeng | 2018 | Cellular & Molecular Immunology2018，15，2： | 0 |
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