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| 1 | 利妥昔单抗联合CHOP方案治疗中国人群弥漫大B细胞淋巴瘤效果及安全性的Meta分析显示文摘目的系统评价利妥昔单抗联合CHOP方案治疗中国人群弥漫大B细胞淋巴瘤的效果及安全性。方法计算机检索2005年1月~2017年6月中国期刊全文数据库、中文科技期刊全文数据库、Pub Med、EMBase、Medline、Cochrane图书馆。收集利妥昔单抗联合CHOP方案(治疗组)对比单用CHOP(对照组)治疗弥漫大B细胞淋巴瘤的随机对照试验(RCT),对符合纳入标准的临床研究进行质量评价和资料提取后,采用Rev Man 5.3软件进行Meta分析。结果共纳入27项RCT,合计患者2134例。Meta结果显示治疗组完全缓解率(OR=2.13,95%CI:1.77~2.57,P<0.01)、总有效率(OR=3.06,95%CI:2.40~3.91,P<0.01)、总生存率(OR=2.40,95%CI:1.89~3.04,P<0.01)均高于对照组,差异有统计学意义。在亚组分析方面,不同疗程的患者在完全缓解率(OR=2.30,95%CI:1.80~2.95,P<0.01)、总有效率(OR=3.41,95%CI:2.51~4.63,P<0.01)方面差异有统计学意义,不同CHOP药物的患者在完全缓解率(OR=2.24,95%CI:1.84~2.72,P<0.01)、总有效率(OR=3.06,95%CI:2.40~3.91,P<0.01)方面差异均有统计学意义。结论利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤的效果及安全性较好。但由于纳入研究的质量等限制,结论有待进一步加以验证。 | 诸慧 李佩涵 金剑 | 2017 | 中国医药导报2017，14，27： | 13 |
| 2 | Prognostic value of pre-and post-transplantation 18F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous stem cell transplantation(ASCT) is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma(NHL).However,a proportion of patients do not respond to ASCT.^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET)/computed tomography(CT) has been widely used for staging,response evaluation,and prognosis prediction.Here,we investigated the prognostic role of PET/CT in NHL patients before and after ASCT.Methods: A retrospective study was conducted at Peking University Cancer Hospital.All NHL patients who underwent ASCT between March 2010 and July 2016 were identified.Patients who had PET/CT scan before and after ASCT were included.Deauville criteria(5-point scale) were used to interpret PET scans.Univariate and multivariate survival analyses were performed using Cox regression.The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic(ROC) curve.Results: In total,79 patients were enrolled in this study.In univariate analysis,pre-and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival(PFS) and overall survival(OS).Patients with negative pre-ASCT PET result demonstrated significantly better PFS(84.2% vs.54.2%) and OS(89.2% vs.63.6%) than patients with positive pre-ASCT PET result.PFS(91.6% vs.25.3%) and OS(96.5% vs.36.8%) were also significantly different between patients with negative and positive post-ASCT PET result.Multivariate analysis also showed a significant association between survival and post-ASCT PET result.ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone.Combined pre-and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation.Deauville criteria score >3 was identified as the best cutoff value for post-ASCT PET.Conclusions: Post-ASCT PET result was more important than pre-ASCT PET result in predicting outcomes for NHL patients who underwent ASCT.The prognostic significance can be improved when combining preASCT PET result with post-ASCT PET result.Deauville criteria can be used for interpreting PET scans in this scenario. | Zhitao Ying Lan Mi Xuejuan Wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei Wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
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