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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | 术前炎性因子水平对82例行结直肠癌根治术患者预后影响研究显示文摘[目的]探讨术前炎性因子水平对行结直肠癌根治术患者预后情况的影响。[方法]82例行结直肠癌根治术的患者作为研究对象,对其术前炎性因子水平及预后情况进行回顾性研究,进行相关性分析。对有差异的因素进行Logistic多因素回归分析。[结果]病理分期及各项术前炎性因子水平均会对患者3年生存率产生影响,差异有统计学意义(P<0.05)。Logistic多因素回归分析结果显示,TNF-α、IL-6、IL-8表达水平以及GPS评分是影响患者预后的独立危险因素。[结论]术前炎性因子对于预测结直肠癌根治术后患者预后具有一定意义,应作为常规检测指标。 | 许柯青 赵靖 崔文贤 | 2016 | 肿瘤学杂志2016，22，12： | 2 |
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