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| 1 | PAR-2和COX-2在不同类型胃食管反流病患者病变组织中表达及与患者血清炎性因子水平关系显示文摘目的探讨蛋白酶激活受体-2(PAR-2)和环氧合酶-2(COX-2)在不同类型胃食管反流病(GERD)患者病变组织中表达及与患者血清炎性因子水平的关系。方法选取GERD患者127例,其中糜烂性食管炎组41例,Barrett食管组43例,非糜烂性反流病组43例,另选取同期内镜检查正常者40例作为对照组,应用RT-PCR技术检测各组食管组织中PAR-2 mRNA和COX-2 mRNA表达情况,利用ELISA法检测血清IL-1β、IL-6、IL-8和TNF-α水平,利用Pearson相关分析对变量间相关关系进行分析。结果各患者组病变组织中PAR-2 mRNA和COX-2 mRNA相对表达量均明显高于对照组(P均<0.05),Barrett食管组和糜烂性食管炎组病变组织中PAR-2 mRNA和COX-2 mRNA相对表达量均明显高于非糜烂性反流病组(P均<0.05),且Barrett食管组病变组织中COX-2 mRNA相对表达量高于糜烂性食管炎组(P<0.05)。各患者组血清IL-1β、IL-6、IL-8和TNF-α水平均明显高于对照组(P均<0.05),Barrett食管组和糜烂性食管炎组血清IL-1β、IL-6、IL-8和TNF-α水平均明显高于非糜烂性反流病组(P均<0.05),且Barrett食管组血清IL-8水平明显高于糜烂性食管炎组(P<0.05)。Pearson相关分析显示,GERD患者病变组织中PAR-2 mRNA和COX-2 mRNA相对表达量均与血清IL-1β、IL-6、IL-8和TNF-α水平呈正相关。结论 PAR-2和COX-2在GERD患者病变组织中呈高表达,且与患者血清炎性因子水平呈正相关,提示炎性反应可能参与了GERD的发生及发展过程。 | 杨梅 | 2016 | 现代中西医结合杂志2016，25，31： | 13 |
| 2 | Bioequivalence of two esomeprazole magnesium enteric-coated formulations in healthy Chinese subjects显示文摘BACKGROUND The pharmacokinetics and bioequivalence of esomeprazole in healthy Chinese subjects and the effects of food on the pharmacokinetics have not been well studied.AIM To evaluate the pharmacokinetic characteristics of esomeprazole magnesium(Eso)enteric-coated capsule in the healthy subjects in China and the bioequivalence of the two formulations.METHODS This study was conducted in the Phase I Clinical Trial Unit of the Affiliated Hospital of Changchun University of Chinese Medicine.A total of 64 healthy subjects were enrolled in the study.Thirty-two subjects fasted or fed,took the test or reference formulation Eso enteric-coated capsule by a four-cycle,two-sequence crossover of fasting/fed,self-controlled method.The liquid chromatographymass spectrometry was performed to determine the drug plasma concentration at 16 different time points within 12 h after drug administration.The pharmacokinetic parameters Cmax,area under the curve(AUC)0-t,and AUC0-inf were calculated to evaluate the bioequivalence.RESULTS Pharmacokinetic parameters were evaluated after subjects took the test formulation and control formulation under fasting status.The ratio of geometric means of Cmax was 104.15%,with a confidence interval(CI)of 98.20-110.46%.The ratio of geometric means of AUC0-t was 105.26%,with a CI of 99.80-111.01%.The ratio of geometric means of AUC0-inf was 105.37%,with a CI of 99.97-111.06%.The pharmacokinetic parameters were also evaluated after subjects took the reference formulation of Eso enteric-coated capsule after eating.The upper limit of 95%CI of the geometric mean ratio of pharmacokinetic parameters of Eso enteric-coated capsules in the postprandial state Cmax was-0.1689,and the point estimate was 0.9509(0.80-1.25).The upper limit of 95%CI of the geometric mean ratio of pharmacokinetic parameters of Eso enteric-coated capsules in the postprandial state AUC0-t was-0.1015(≤0),and the point estimate was 0.9003(0.80-1.25).The upper limit of 95%CI of the geometric mean ratio of pharmacokinetic parameters of Eso enteric-coated capsules in the postprandial state AUC0-inf was-0.0593(≤0),and the point estimate was 0.8453(0.80-1.25).The results indicated that the two formulations were bioequivalent under both fasting and fed states.CONCLUSION The two types of esomeprazole tablets were bioequivalent under both fasting and fed states,and both were generally well tolerated. | Zheng-Zhi Liu Qing Ren Yan-Nan Zhou Hai-Miao Yang | 2020 | World Journal of Clinical Cases2020，8，22： | 2 |
| 3 | 应用Het-1A细胞系研究CDDO-Me对食管黏膜上皮屏障的保护作用显示文摘目的观察CDDO-Me对食管黏膜屏障的保护效应,探讨CDDO-Me作为黏膜屏障增强剂的可行性。方法分别以不同pH值的酸(pH4、pH5、pH6)处理Het-1A细胞系,处理时间为5、10、30、60 min,检测各组Het-1A细胞系跨上皮电阻抗(TEER)值的变化;以含不同浓度的CDDO-Me(0、0.25、0.5、1、2.5、5μmol/L)预刺激Het-1A细胞系,再以酸处理Het-1A细胞系,观察TEER值的变化。结果pH为4、5、6时,不同处理时间对Het-1A细胞的TEER作用比较差异均有统计学意义(P<0.01),随着处理时间(10、30、60 min)的延长,TEER下降幅度越大。处理时间为10、30、60 min时,各组间差异均有统计学意义,以pH4组60 min时TEER下降最明显(P<0.01)。CDDO-Me预刺激后以pH4酸处理Het-1A细胞系,12、24、48 h时,不同浓度CDDO-Me预刺激组TEER比较差异均有统计学意义(P<0.05),24 h时,随着刺激浓度的增加,各组TEER逐渐升高,以5μmol/L组最明显(P<0.05);浓度为0.5、1、2.5、5μmol/L时,各组间差异均有统计学意义(P<0.05)。结论酸损害食管上皮屏障功能,与酸度和作用时间有关;CDDO-Me对于酸对食管上皮屏障的损害有保护作用。 | 程凌雪 范永强 侯超 李文波 | 2021 | 天津医药2021，49，1： | 1 |
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