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| 1 | Modeling the density gradient of 3D nanofiber scaffolds fabricated by divergence electrospinning显示文摘Following recent insights on structure-cell-function interactions and the critical role of the extracellular matrix(ECM),the latest biofabrication approaches have increasingly focused on designing materials with biomimetic microarchitecture.Divergence electrospinning is a novel fabrication method for three-dimensional(3D)nanofiber scaffolds.It is introduced to produce 3D nanofiber mats that have numerous applications in regenerative medicine and tissue engineering.One of the most important characteristics of 3D nanofiber mats is the density gradient.This study provides a statistical analysis and response surface modeling framework based on experimental data to evaluate the manner by which the geometric designs of double-bevel collectors influence the fiber density gradient.Specifically,variance of analysis and sensitivity analysis were performed to identify parameters that had significant effects,and a response surface model embedded with seven location indicators was developed to predict the spatial distribution of fiber density for different collector designs.It was concluded that the collector height,bevel angle,and their interactions were significant factors influencing the density gradient.This study revealed the sensitivity of system configuration and provided an optimization tool for process controllability of microstructure gradients. | Muhammad Adib Uz Zaman Dilshan Sooriyaarachchi Ying-Ge Zhou George Z.Tan Dong-Ping Du | 2021 | Advances in Manufacturing2021，9，3： | 1 |
| 2 | Fabrication of Dual-pore Scaffolds Using a Combination of Wire-Networked Molding (WNM) and Non-solvent Induced Phase Separation (NIPS) Techniques显示文摘 | Dong Guk Sohn Myoung Wha Hong Young Yul Kim Young-Sam Cho | 2015 | Journal of Bionic Engineering2015，12，4： | 1 |
| 3 | Recent Progress in the Biological Basis of Remodeling Tissue Regeneration Using Nanofibers:Role of Mesenchymal Stem Cells and Biological Molecules显示文摘Opening up new and unlimited avenues in the biomedical field,tissue engineering and regenerative medicine,the electrospinning process is considered as a versatile and the most preferred technique for the fabrication of nanofibers.These tailor-designed nanofibers provide a desirable and bio-inspired physiological niche to cells for better attachment and subsequent proliferation.In this review,an attempt is made to explain the importance of various topological and morphological parameters of nanofibrous scaffolds for efficient bio-mimicking.Some novel approaches(e.g.,appropriate functionalization and extracellular matrix derived from decellularization)utilized for better mimicking and exponential growth of regenerating tissues are also discussed.Furthermore,this review highlights the important parameters necessary for the attachment,proliferation and differentiation of the mesenchymal stem cells for tissue regeneration.The importance of growth factors and their role after introducing the electrospinning techniques for efficient delivery and their role in the proliferation of mesenchymal stem cells in the different specific lineage(e.g.,tenogenic,chondrogenic,neurogenic and osteogenic differentiation)are discussed. | Roqia Ashraf Hasham S.Sofi Hern Kim Faheem A.Sheikh | 2019 | Journal of Bionic Engineering2019，16，2： | 0 |
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