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| 1 | Fatty liver diseases, mechanisms, and potential therapeutic plant medicines显示文摘The liver is an important metabolic organ and controls lipid, glucose and energy metabolism. Dysruption of hepatic lipid metabolism is often associated with fatty liver diseases, including nonalcoholic fatty liver disease(NAFLD), alcoholic fatty liver diseases(AFLD) and hyperlipidemia. Recent studies have uncovered the contribution of hormones, transcription factors, and inflammatory cytokines to the pathogenesis of dyslipidemia and fatty liver diseases. Moreover, a significant amount of effort has been put to examine the mechanisms underlying the potential therapeutic effects of many natural plant products on fatty liver diseases and metabolic diseases. We review the current understanding of insulin, thyroid hormone and inflammatory cytokines in regulating hepatic lipid metabolism, focusing on several essential transcription regulators, such as Sirtuins(SIRTs), Forkhead box O(FoxO), Sterol-regulatory element-binding proteins(SREBPs). We also discuss a few representative natural products with promising thereapeutic effects on fatty liver disease and dyslipidemia. | ZHU Jia-Zhen YI Hong-Wei HUANG Wei PANG Tao ZHOU Hui-Ping WU Xu-Dong | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 7 |
| 2 | 基于脂代谢特点建立豚鼠动脉粥样硬化模型优势的研究进展显示文摘动脉粥样硬化(AS)在全球的发病率逐年升高,有关AS的研究也越来越深入,合适的动物模型是研究动脉粥样硬化机制和药物研发的关键环节。在众多动物模型中豚鼠作为动脉粥样硬化的研究对象存在众多优势,主要体现在血浆脂蛋白的构成比例、胆固醇的转运形式、肝脏中胆固醇的存在形式与比例、对外源性胆固醇的敏感性、胆固醇与脂蛋白代谢过程中关键酶的活性变化等方面。本综述基于脂代谢特点,对比分析这几个方面内容来阐述豚鼠作为动脉粥样硬化动物模型的优势。 | 郭媛媛 王点 李悠 安雪晶 龚立博 郭茂娟 | 2015 | 现代生物医学进展2015，15，34： | 1 |
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