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| 1 | 青光眼视功能损害的血流动力学显示文摘青光眼是一种严重的不可逆性致盲眼病,是以视网膜神经纤维缺失、视神经结构及视功能相关改变为特征的多因子视神经病〔1〕。其视神经损害的发病机制尚未完全清楚。许多青光眼患者在眼压得到有效控制后依然出现进行性视功能损害。因此除眼压外,缺血性改变是青光眼发生发展的另一个重要因素。本文就青光眼视功能损害的血流动力学研究进行综述。 | 胡丹萍 贺冰 高怡红 | 2014 | 中国老年学杂志2014，34，8： | 11 |
| 2 | Damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma显示文摘AIM:To observe the differences of damage patterns of retinal nerve fiber layer(RNFL)between acute and chronic intraocular pressure(IOP)elevation in primary angle closure glaucoma(PACG)using optical coherence tomography(OCT). METHODS:Twenty-four patients(48 eyes)with unilateral acute PACG(APACG)attack in the 6 months after admission and 36 patients(64 eyes)with chronic PACG(CPACG)were included in this prospective study.For all cases,IOP has been controlled under 21mmHg after treatment.Using stratus OCT, the RNFL thickness was assessed in eyes with PACG within 3 days,2 weeks,1,3 and 6 months after IOP was controlled. Repeated measures ANOVA was used to examine the changes of RNFL thickness at different time after IOP being controlled in both acute attack eyes and unaffected fellow eyes of APACG and eyes with CPACG. RESULTS:The mean RNFL thickness for the APACG-attacked eyes increased significantly within 3 days(121.49±23.84)μm after acute onset and then became thinner along with time[(107.22±24.72)μm at 2 weeks,(93.58±18.37)μm at 1 month,(84.10±19.89)μm at 3 months and(78.98±19.17)μm at 6 months].In APACG-attacked eyes,there were significant differences of average RNFL thickness at 5 different times after IOP was controlled(P<0.001).In the APACG unaffected fellow eyes and CPACG eyes,there were no significant differences in mean RNFL thickness at 5 different times(F=0.450,P=0.104 in APACG unaffected fellow eyes and F=1.558,P=0.200 in CPACG eyes).There was significant difference for interaction between time periods and groups(F=1.912,P=0.003). CONCLUSION:RNFL damage patterns are different under different IOP elevated courses.In APACG,RNFL was found to be swollen and thickening right after acute attack and then becomes thinning and atrophy along with the time,while RNFL was found to be diffused thinness in CPACG. | Xing Liu Mei Li Yi-Min Zhong Hui Xiao Jing-Jing Huang and Xiang-Yun Kong | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 4 |
| 3 | 彩色多普勒在青光眼研究中的应用进展显示文摘彩色多普勒成像(color Doppler flow imagine,CDI)技术因为无创、重复性好等优点在眼科应用广泛,能检测眼部血管的血流动力学,在眼底血管病变的临床诊断、药物和手术的评价疗效以及和血流变化有关的眼病机制研究等方面有重要价值。现就CDI在青光眼研究中的应用进展综述如下。 | 王娜 姜发纲 | 2008 | 国际眼科杂志2008，8，9： | 3 |
| 4 | 原发性闭角型青光眼眼压与眼球后血流动力学改变的相关研究显示文摘目的:研究原发性闭角型青光眼(PACG)眼动脉(OA)、视网膜中央动脉(CRA)血流动力学改变及眼压(IOP)对眼球后血流动力学的影响。方法:PACG患者45例(90眼),并根据IOP情况分为正常IOP组(52眼)与高IOP组(38眼)。应用彩色多普勒成像技术研究PACG眼球后OA、CRA血流动力学改变。观察指标:收缩期最大血流速度(PSV)、舒张末期血流速度(EDV)、搏动指数(PI)、阻力指数(RI)。彩色多普勒检查前采用非接触IOP计测量受检者IOP。结果:PACG患者CRA-EDV(P<0.01),CRA-RI(P<0.01)均显著不同于正常对照组,且患者正常IOP组与高IOP组之间亦有显著性差异(P<0.01)。CRA-EDV呈逐级降低趋势。CRA-RI的表现与CRA-EDV相反,呈逐级增高现象。无论是CRA还是OA,三组间PSV均无显著性差异。相关分析表明:PACGIOP与CRA-RI(r=0.51;P=0.001)及CRA-EDV(r=-0.396;P=0.014)显著相关。偏相关分析显示:IOP与CRA-RI显著相关(r=0.393;P<0.001),而与CRA-EDV无显著相关(r=-0.065;P=0.559)。其回归方程为:RI=58.82+0.47×IOP。结论:IOP对OA无显著影响。PACGIOP升高可导致CRA-RI增高,继而使EDV降低,视网膜血流量下降。 | 田农 潘丽娟 付宁华 | 2008 | 医学研究生学报2008，21，2： | 1 |
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