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| 1 | 草鱼呼肠孤病毒研究进展显示文摘草鱼(Ctenopharyngodon idellus)是我国淡水养殖的主要品种,为四大家鱼之一,尤其在我国气候温暖的南方如长江、珠江水域养殖量极大。然而草鱼在幼苗阶段极易发病,其中威胁最大是草鱼出血病(grass carp hemorrhage),死亡率可高达90%以上。草鱼呼肠孤病毒(grass carp reovirus,GCRV)是草鱼出血病的主要病原,由于其高度传染性与致死性,对我国草鱼养殖业造成了极大的损失。近年来,关于草鱼呼肠孤病毒的研究逐步增多,并且出现了新基因型报道,引起了多方关注。对草鱼呼肠孤病毒的病原学、分子生物学、免疫原性、检测和综合防治等进行综述,并展望未来的研究方向,旨在对该病的防治和深入研究提供指导。 | 杨映 于辉 古勇明 | 2015 | 广东农业科学2015，42，15： | 9 |
| 2 | 草鱼呼肠孤病毒疫苗的研发与应用显示文摘随着水产养殖产业的不断扩大,我国已成为世界上最大的水产品生产消费和进出口国家。2000年至2013年,水产养殖产量以每年5%~6%稳步增长,在2013年,中国水产养殖产量达4.542×10~7t,占全球水产养殖总产量的60%以上[1]。根据世界粮农组织数据显示,2015年我国水产养殖总量达7.430×107 t。这些数据表明我国水产养殖业不仅保障了中国水产品的市场供应, | 高岩 裴超 张超 李筝 孔祥会 | 2017 | 水产科学2017，36，2： | 7 |
| 3 | 草鱼呼肠孤病毒和草鱼的干扰素抗病毒免疫研究进展显示文摘草鱼出血病给草鱼养殖业造成了巨大的经济损失,其主要病毒性病原是草鱼呼肠孤病毒。文章首先从病毒基因组及其编码蛋白的功能和病毒的细胞培养特性方面总结了草鱼呼肠孤病毒的生物学特征;然后介绍了呼肠孤病毒的生活周期和致病机理;最后概述了草鱼的干扰素抗病毒免疫的最新进展,从草鱼呼肠孤病毒和宿主的抗病毒免疫两个方面来阐述草鱼出血病的发病机理,以期为研究和防控草鱼呼肠孤病毒病提供相关参考。 | 孙效迎 宋华丽 张超 李莉 孔祥会 裴超 | 2019 | 黑龙江畜牧兽医2019，0，15： | 2 |
| 4 | Identification and characterization of two cleavage fragments from the Aquareovirus nonstructural protein NS80显示文摘Aquareovirus species vary with respect to pathogenicity,and the nonstructural protein NS80 of aquareoviruses has been implicated in the regulation of viral replication and assembly,which can form viral inclusion bodies(VIBs) and recruit viral proteins to its VIBs in infected cells.NS80 consists of 742 amino acids with a molecular weight of approximately 80 kDa.Interestingly,a short specific fragment of NS80 has also been detected in infected cells.In this study,an approximately58-kDa product of NS80 was confirmed in various infected and transfected cells by immunoblotting analyses using α-NS80 C.Mutational analysis and time course expression assays indicated that the accumulation of the 58-kDa fragment was related to time and infection dose,suggesting that the fragment is not a transient intermediate of protein degradation.Moreover,another smaller fragment with a molecular mass of approximately 22 kDa was observed in transfected and infected cells by immunoblotting with a specific anti-FLAG monoclonal antibody or α-NS80 N,indicating that the 58-kDa polypeptide is derived from a specific cleavage site near the amino terminus of NS80.Additionally,different subcellular localization patterns were observed for the 22-kDa and 58-kDa fragments in an immunofluorescence analysis,implying that the two cleavage fragments of NS80 function differently in the viral life cycle.These results provide a basis for additional studies of the role of NS80 played in replication and particle assembly of the Aquareovirus. | Qingxiu Chen Jie Zhang Fuxian Zhang Hong Guo Qin Fang | 2016 | Virologica Sinica2016，31，4： | 1 |
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