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| 1 | Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage显示文摘The tooth belongs to the trigeminal sensory pathway.Dental damage has been associated with impairments in the central nervous system that may be mediated by injury to the trigeminal nerve.In the present study,we investigated the effects of damage to the inferior alveolar nerve,an important peripheral nerve in the trigeminal sensory pathway,on learning and memory behaviors and structural changes in related brain regions,in a mouse model of Alzheimer's disease.Inferior alveolar nerve transection or sham surgery was performed in middle-aged(4-monthold) or elderly(7-month-old) senescence-accelerated mouse prone 8(SAMP8) mice.When the middle-aged mice reached 8 months(middle-aged group 1) or 11 months(middle-aged group 2),and the elderly group reached 11 months,step-down passive avoidance and Y-maze tests of learning and memory were performed,and the cholinergic system was examined in the hippocampus(Nissl staining and acetylcholinesterase histochemistry) and basal forebrain(choline acetyltransferase immunohistochemistry).In the elderly group,animals that underwent nerve transection had fewer pyramidal neurons in the hippocampal CA1 and CA3 regions,fewer cholinergic fibers in the CA1 and dentate gyrus,and fewer cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band,compared with sham-operated animals,as well as showing impairments in learning and memory.Conversely,no significant differences in histology or behavior were observed between middle-aged group 1 or group 2 transected mice and age-matched sham-operated mice.The present findings suggest that trigeminal nerve damage in old age,but not middle age,can induce degeneration of the septal-hippocampal cholinergic system and loss of hippocampal pyramidal neurons,and ultimately impair learning ability.Our results highlight the importance of active treatment of trigeminal nerve damage in elderly patients and those with Alzheimer's disease,and indicate that tooth extraction should be avoided in these populations. | Yifan He Jihong Zhu Fang Huang Liu Qin Wenguo Fan Hongwen He | 2014 | Neural Regeneration Research2014，9，22： | 2 |
| 2 | NADPH-d在大鼠三叉神经脊束核的表达显示文摘目的探究还原型烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate,NADPH)在三叉神经脊束核(spinaltrigeminal nucleus,STN)的表达情况。方法 2015年8月,选择雌性大鼠六只,取三叉神经脊束核冰冻切片,采用NADPH-d化学组织染色。结果 NADPH-d在STN存在表达。结论一氧化氮/一氧化氮合酶系统可能参与颌面部感觉传导调控。 | 刘永亮 丁桂聪 | 2017 | 大医生2017，2，6： | 1 |
| 3 | NADPH-d在大鼠三叉神经节的表达显示文摘目的探究还原型烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate,NADPH)在三叉神经节(trigeminal ganglion,TG)的表达情况。方法 2015年5月,选择雌性大鼠6只,取双侧三叉神经节冰冻切片,采用NADPH-d化学组织染色。结果 NADPH-d在TG存在表达,中小细胞染色深于大细胞,阳性细胞以中小体积为主,占73.2%。结论一氧化氮/一氧化氮合酶系统可能参与颌面部感觉传导调控。 | 刘永亮 丁桂聪 | 2018 | 系统医学2018，3，1： | 0 |
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