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| 1 | Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion显示文摘The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely evaluated.This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO.Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days.After reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group.The expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex group.Increased MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct region.There was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St groups.Our study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic stroke.Furthermore,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function recovery.All experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126). | Min Cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim | 2019 | Neural Regeneration Research2019，14，7： | 7 |
| 2 | Secondary parkinsonism induced by hydrocephalus after subarachnoid and intraventricular hemorrhage显示文摘Hydrocephalus can induce secondary parkinsonism(Shahar et al.,1988;Aggarwal et al.,1997;Racette et al.,2004).Physical factors such as increased ventricular pressure near the upper midbrain and basal ganglia are thought to cause mechanical disruption of dopaminergic systems(i.e.,the nigrostriatal pathways from the medial substantia nigra to the caudate nuclei and putamen and its frontal projection fibers from the basal ganglia) | Min Cheol Chang Min Ho Chun | 2016 | Neural Regeneration Research2016，11，8： | 1 |
| 3 | Detection of thinned corticospinal tract and corticoreticular pathway in a patient with a calf circumference discrepancy显示文摘In clinical practice,it is challenging to elucidate the location of the lesion in a patient’s nervous system that is causing the neurologic symptoms,because lesions are often microscopic and cannot be revealed by conventional evaluation methods.However,recently developed techniques may aid clinicians in detecting these microscopic lesions.In particular,diffusion tensor tractography(DTT),derived from diffusion tensor | han do lee min cheol chang | 2018 | Neural Regeneration Research2018，13，2： | 0 |
| 4 | 大脑中动脉狭窄对心房纤颤患者急性缺血性脑卒中的影响显示文摘目的心源性栓塞是心房纤颤(AF)患者发生急性缺血性脑卒中(AIS)最主要病因。大脑中动脉(MCA)支配区AIS是最常见的。研究MCA狭窄(MCAS)与AF患者发生的MCA支配区AIS发病机制的关系。方法选择AIS同时伴有AF的患者232例,其中男性140例,女性92例;年龄57~85岁,平均年龄74.2岁。根据MCA狭窄程度,将AIS患者分为MCAS组(MCA狭窄率≥70%)与大脑中动脉非狭窄(MCANS)组,分别比较两组患者的基本信息、危险因素、临床特点和影像学特点。结果 MCAS患者27例,MCANS患者205例。与MCANS患者相比,MCAS患者高血压发病率较高(P〈0.01),而心脏病发病率偏低(P〈0.05)。MCANS组入院时美国国立卫生院卒中量表(NIHSS)评分(P=0.01)、出院时改良Rankin量表(m RS)评分(P〈0.01)及左心房前后径(LAD;P=0.03)皆高于MCAS组。腔隙性AIS在MCAS组中更多见(P=0.04),而多发性AIS在MCANS组中更普遍(P〈0.01)。结论 AF患者发生MCA支配区AIS时,MCA动脉硬化病变可能与AIS不同分型存在相关性。MCA轻中度狭窄时发生心源性AIS中的概率更高。MCA严重狭窄时动脉粥样硬化性AIS的发生率更高。 | 宋静杰 路雅宁 师聪红 吴跃华 景艳 穆耀强 | 2016 | 生物医学工程与临床2016，20，1： | 0 |
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