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| 1 | 细胞器不依赖于DNA的复制——中心体自主复制解读显示文摘有关细胞成分在严格的条件下复制自身的机制,还有很多谜团.协助成对染色体分离的中心体(以及其他细胞器)可在合适的时间自主复制,并且不需要DNA作为向导.这种独立性还有待一步步揭示.本文通过中心体复制和中心体周期调控方面的大量研究成果,特别是近年来的新进展,从4个方面诠释了这种'独立性':在中心体的'独立'复制和DNA复制-遗传物质稳定控制的上游,具有总揽性的统一基础,因而虽'独立'却不'孤立'或无本;多功能的激酶Plk1等核心调控因子及相关分子复合结构协调了中心体周期和染色体/DNA周期;类似'感应开关'效应的结构形成和转变起止模式,精密地控制了中心体复制及其周期;中心体结构复制及其周期调控在有统一基础的框架内分化、适应,是以多环节、多途径过程产生特异功能体的典型例子. | 梁前进 | 2017 | 科学通报2017，62，13： | 4 |
| 2 | MoS_(2)-based nanocomposites for cancer diagnosis and therapy显示文摘Molybdenum is a trace dietary element necessary for the survival of humans.Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body(such as xanthine oxidase,aldehyde oxidase and sulfite oxidase).Many molybdenum-based compounds have been widely used in biomedical research.Especially,MoS_(2)-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties.MoS_(2)can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area,improving its tumor targeting and colloidal stability,as well as accuracy and sensitivity for detecting specific biomarkers.At the same time,in the near-infrared(NIR)window,MoS_(2)has excellent optical absorption and prominent photothermal conversion efficiency,which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release.Significantly,the modified MoS_(2)-nanocomposite can specifically respond to the tumor microenvironment,leading to drug accumulation in the tumor site increased,reducing its side effects on non-cancerous tissues,and improved therapeutic effect.In this review,we introduced the latest developments of MoS_(2)-nanocomposites in cancer diagnosis and therapy,mainly focusing on biosensors,bioimaging,chemotherapy,phototherapy,microwave hyperthermia,and combination therapy.Furthermore,we also discuss the current challenges and prospects of MoS_(2)-nanocomposites in cancer treatment. | Jianling Wang Lihua Sui Jia Huang Lu Miao Yubing Nie Kuansong Wang Zhichun Yang Qiong Huang Xue Gong Yayun Nan Kelong Ai | 2021 | Bioactive Materials2021，6，11： | 0 |
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