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    题名 作者 年代 出处 被引量
1手性药物分析方法研究进展显示文摘综述了近10年来手性药物分离检测方法的发展,包括高效液相色谱法、气相色谱法、毛细管电泳法,以及超临界流体色谱法等,旨在为该领域的进一步发展提供参考。杨沐 钟文英 侯雯 2014药学进展2014,38,3:7
2Colorimetric enantiodiscrimination of mandelic acid by indicator displacement assay显示文摘The colorimetric enantiodiscrimination between mandelic acid and L-proline-Cu(II) is exploited to develop enantioselective indicator displacement assays. The sensitivity of the assay could be tuned by using a colorimetric indicator. The chromophoric ligand, pyrocatechol violet, effectively competes with the mandelic acid guest for open coordination sites on L-proline-Cu(II). The DA could be increased to 0.12 by changing the ratio of(+)- and(à)-mandelic acid concentrations that were found to be optimal from the displacement experiments. The resultant enantiomer excess versus DA relationship is linear. From the calibration curves, the absorbance values of the unknowns may be calculated for the enantiomeric excess value and the colorimetric enantiodiscrimination of mandelic acid can thus be obtained.Xue-Xian Chen Li-Ming Yuan 2015Chinese Chemical Letters2015,26,8:1
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