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| 1 | Large animal ischemic stroke models: replicating human stroke pathophysiology显示文摘The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions.Although promising therapeutics have been identified using these animal models,with most undergoing significant testing in rodent models,the vast majority of these interventions have failed in human clinical trials.This failure of preclinical translation highlights the critical need for better therapeutic assessment in more clinically relevant ischemic stroke animal models.Large animal models such as non-human primates,sheep,pigs,and dogs are likely more predictive of human responses and outcomes due to brain anatomy and physiology that are more similar to humans-potentially making large animal testing a key step in the stroke therapy translational pipeline.The objective of this review is to highlight key characteristics that potentially make these gyrencephalic,large animal ischemic stroke models more predictive by comparing pathophysiological responses,tissue-level changes,and model limitations. | Erin E.Kaiser Franklin D.West | 2020 | Neural Regeneration Research2020，15，8： | 11 |
| 2 | 缺血性卒中的动物模型与人类卒中的比较研究状况显示文摘影响脑卒中的因素众多,如缺血持续时间和缺血严重程度、侧支循环系统和全身血压、病原学和梗塞部位,以及年龄、性别、各种治疗的并发症和遗传背景等。因侧重方面不同,脑卒中的实验动物模型不同,需选用合适的动物模型模拟人类卒中的实际情况,以期得到更准确的研究结果。本文对各种动物模型的优缺点以及动物模型与人类实际情况的对比进行综述。 | 贾啟澜 于萍 吕莉 | 2019 | 中国临床药理学杂志2019，35，9： | 3 |
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