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| 1 | New Insights into the Molecular Basis of Kidney Governing Bone Theory显示文摘Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney prescriptions/herbs are widely used in Traditional Chinese Medicine(TCM). However, the exact biological basis of kidney governing bone theory in the context of new advances in biology is still not fully established. In this paper, the content of kidney governing bone theory in biology has been fully demonstrated from different aspects. We first propose that bone and kidney mutually affect each other in pathology and physiology, particularly through homeostasis of calcium, phosphorus and fibroblast growth factor-23(FGF-23). Next, we identify that tonifying kidney prescriptions/herbs exert bone protective effects, thus treating osteoporosis by regulating bone formation and bone resorption.Furthermore, the exact molecular mechanisms of tonifying kidney prescriptions, herbs and their effective components in treating osteoporosis have been systematically reviewed. Finally, we come into the conclusion that kidney regulating bone mineral homeostasis, bone protective effects of tonifying kidney herbs and regulatory effects on bone homeostasis are all the manifestations of kidney governing bone theory.Therefore, the new insights into kidney governing bone theory in biology will promote the development of clinical practices, and drugs discovery in treating osteoporosis. | Dong-feng Zhao Yong-jian Zhao Cheng-long Wang Yan-ping Yang Yong-jun Wang | 2015 | World Journal of Traditional Chinese Medicine2015，1，3： | 2 |
| 2 | 按摩对兔骨骼肌损伤修复自由基相关酶的活性的影响显示文摘目的通过检测按摩对兔骨骼肌钝挫伤修复过程中谷胱甘肽过氧化物酶(GSH-Px)、髓过氧化物酶(MPO)活力值,及细胞磷脂酶A2(PLA2)mRNA表达的影响,探讨按摩加快清除肌肉损伤修复过程中自由基的作用机制。方法选取新西兰大白兔42只,随机分为4组,即正常对照组(A组,n=3)、损伤组(B组,n=3)、按摩组(C组,n=18,包括损伤后第5d和第10d各9只)和自然恢复组(D组,n=18,包括损伤后第5d和第10d各9只)。A组实验兔不作处理,作为正常对照;B、C、D组实验动物用自制打击器来制备兔左后肢股四头肌损伤模型。C组于造模后第4天用按摩器施以按摩治疗,1次/天至处死取材;B、D组不进行按摩。各组于伤后5d及10d活体心脏取血,用于进行生化指标检测GSH-Px和MPO的活力值;取股四头肌样本,进行HE染色和实时荧光定量PCR法检测PLA2mRNA的相对表达量,并同A组正常股四头肌检测结果进行比较。结果正常组、损伤组、伤后5d及10d按摩组和自然恢复组的GSH-Px和MPO活力值经比较,按摩组较自然恢复组明显减少(P<0.05);经按摩干预后,各组的PLA2mRNA表达量也显示,按摩组明显比自然恢复组减少(P<0.05)。结论按摩可促进兔股四头肌损伤的修复过程,其机制可能是按摩能够通过加快清除损伤后自由基的产生,使中性粒细胞浸润减少,降低PLA2活性来保护细胞结构完整性,减轻疼痛。 | 谢辉 唐成林 陈晓琳 唐念珍 | 2014 | 中国组织化学与细胞化学杂志2014，23，1： | 1 |
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