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| 1 | Controllable Synthesis of Fluorescent Carbon Dots and Their Detection Application as Nanoprobes显示文摘Carbon dots(CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because of their outstanding water solubility, high sensitivity and selectivity to target analytes, low toxicity, favorable biocompatibility, and excellent photostability, researchers from diverse disciplines have come together to further develop the fundamental properties of CDs. Many methods for the production of CDs have been reported, therein, hydrothermal and solvothermal technology needs simple equipments, and microwave synthesis needs less reaction time, hence these methods become current common synthesis methods, in which many precursors have been applied to produce CDs. Due to their excellent fluorescence, CDs have made impressive strides in sensitivity and selectivity to a diverse array of salt ions,organic/biological molecules and target gases. The development of CDs as nanoprobes is still in its infancy, but continued progress may lead to their integration into environmental and biological applications. Hydrothermal,solvothermal, and microwave synthesis of fluorescent carbon dots and their detection applications as nanoprobes in salt ions, organic/biological molecules, and target gases will be reviewed. | Zhi Yang Zhaohui Li Minghan Xu Yujie Ma Jing Zhang Yanjie Su Feng Gao Hao Wei Liying Zhang | 2013 | Nano-Micro Letters2013，5，4： | 12 |
| 2 | 应用于生物医疗领域的碳纳米点及其复合物显示文摘碳纳米点作为新兴的碳纳米材料,具备制备成本低、尺寸小、低毒、生物相容性高、水溶性好、易修饰、光物理性质独特等诸多优点,在生物医疗领域展现了独有的优势和应用前景。由于具有丰富的表面官能团,碳纳米点可以与靶向配体、医学影像造影剂、核酸、化学药物、光敏剂、光热转换试剂等功能性诊断治疗试剂相互作用形成复合物。目前,碳纳米点及其复合物在医学影像、基因治疗、化学药物治疗、光热、光动力治疗等生物医学诊断治疗领域的应用正在被广泛的开发和报道。这些工作对开发基于碳纳米点的医学诊断治疗试剂及其临床推进具有重要意义,为推进人类重大疾病的个体化、可视化、非入侵式、小损伤的诊断治疗提供一种新的药物体系。本文将关注应用于诊断治疗领域的碳纳米点及其复合物的设计、构建及性能研究,对已报道的基于碳纳米点的诊断治疗试剂在生物医疗领域的研究进展进行总结和讨论。 | 王晓筠 李波 陈力 李迪 曲松楠 李志民 | 2018 | 中国光学2018，11，3： | 2 |
| 3 | Listen to the chemical and histological information in biological tissue显示文摘Photoacoustic imaging(PAI),as an emerging biomedicine diagnostic technique that has been developed quickly in the past decade,inherits the high spatial resolution of ultrasonography in imaging deep tissue and the high sensitivity of optical imaging in evaluating tissue chemical and physiological information.In this paper,after introducing the basic principles of PAI including both photoacoustic tomography and photoacoustic microscopy,we will review some recent progress of PAI in biomedicine and demonstrate the capability of PAI in detecting the chemical compositions and in evaluating the histological microstructures in biological tissue. | Jie Yin Fei Zhao Chao Tao Xue-Ding Wang Xiao-Jun Liu | 2015 | Chinese Chemical Letters2015，26，4： | 0 |
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