共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 粒细胞集落刺激因子对实验性脑出血大鼠血肿周围组织中Bax及Bcl-2蛋白表达的影响显示文摘目的探讨粒细胞集落刺激因子对实验性脑出血大鼠血肿周围组织中Bax及Bcl-2蛋白表达的影响。方法将成年雄性SD大鼠随机分为假手术组、脑出血组、处理组,采用称重法测定脑组织的含水量,采用Western印迹法检测脑组织中Bax及Bcl-2的蛋白表达情况。结果结果:1脑水肿程度:手术后6、12、24、48 h时,脑出血组大鼠的脑组织含水量高于假手术组,治疗组大鼠的脑组织含水量低于脑出血组;2Bax及Bcl-2蛋白表达:脑出血组大鼠脑组织Bcl-2的蛋白含量低于假手术组,Bax的蛋白含量高于假手术组;治疗组大鼠大鼠脑组织Bcl-2的蛋白含量高于脑出血组,Bax的蛋白含量低于脑出血组。结论粒细胞集落刺激因子治疗能够改善实验性脑出血大鼠的脑组织水肿程度、调节Bax及Bcl-2表达、抑制细胞凋亡,可能成为治疗脑出血的理想方法。 | 肖兴花 | 2015 | 中国老年学杂志2015，35，11： | 9 |
| 2 | Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage显示文摘The tooth belongs to the trigeminal sensory pathway.Dental damage has been associated with impairments in the central nervous system that may be mediated by injury to the trigeminal nerve.In the present study,we investigated the effects of damage to the inferior alveolar nerve,an important peripheral nerve in the trigeminal sensory pathway,on learning and memory behaviors and structural changes in related brain regions,in a mouse model of Alzheimer's disease.Inferior alveolar nerve transection or sham surgery was performed in middle-aged(4-monthold) or elderly(7-month-old) senescence-accelerated mouse prone 8(SAMP8) mice.When the middle-aged mice reached 8 months(middle-aged group 1) or 11 months(middle-aged group 2),and the elderly group reached 11 months,step-down passive avoidance and Y-maze tests of learning and memory were performed,and the cholinergic system was examined in the hippocampus(Nissl staining and acetylcholinesterase histochemistry) and basal forebrain(choline acetyltransferase immunohistochemistry).In the elderly group,animals that underwent nerve transection had fewer pyramidal neurons in the hippocampal CA1 and CA3 regions,fewer cholinergic fibers in the CA1 and dentate gyrus,and fewer cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band,compared with sham-operated animals,as well as showing impairments in learning and memory.Conversely,no significant differences in histology or behavior were observed between middle-aged group 1 or group 2 transected mice and age-matched sham-operated mice.The present findings suggest that trigeminal nerve damage in old age,but not middle age,can induce degeneration of the septal-hippocampal cholinergic system and loss of hippocampal pyramidal neurons,and ultimately impair learning ability.Our results highlight the importance of active treatment of trigeminal nerve damage in elderly patients and those with Alzheimer's disease,and indicate that tooth extraction should be avoided in these populations. | Yifan He Jihong Zhu Fang Huang Liu Qin Wenguo Fan Hongwen He | 2014 | Neural Regeneration Research2014，9，22： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员