| 1 | Current treatment options for colon cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis(PC),the dissemination of cancer cells throughout the lining of the abdominal cavity,is the second most common presentation of colon cancer distant metastasis.Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years,it has been repeatedly shown that these therapies remain ineffective for colon cancer PC.Recently,there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC) prolongs the life of colon cancer PC patients.Here,we will review the clinical presentation,the mechanisms of disease progression,and current treatment options for colon cancer PC,with a focus on the benefits and limitations of CRSHIPEC. | Tomoyoshi Aoyagi Krista P Terracina Ali Raza Kazuaki Takabe | 2014 | World Journal of Gastroenterology2014，20，35： | 15 |
| 3 | 热疗联合化疗对中晚期食管癌的疗效观察显示文摘目的观察热疗联合化疗对中晚期食管癌患者的疗效及安全性。方法回顾分析我院2008年10月3日至2014年10月9日有明确病理的中晚期食管癌患者136例,按数字表随机原则分组的方法分为单纯化疗组(A组)和化疗联合热疗组(B组)。其中A组68例,给予紫杉醇175 mg/m2,静脉滴注,第1天,卡培他滨1 000mg/m2,口服,第1~14天,顺铂75mg/m2,静脉滴注,分为第2~4天,21d为1个周期,每例患者至少化疗2个周期;B组68例采用同样方案化疗,第1天同时配合全身热疗,使全身温度升至40~42℃,维持90min。2个周期后观察A组和B组患者的近期疗效及毒副反应。结果 A组中完全缓解(CR)0例,部分缓解(PR)27例,稳定(SD)26例,进展(PD)15例,有效率(CR+PR)为39.7%;B组中CR 3例,PR 41例,SD 18例,PD6例,CR+PR为64.7%。2组比较差异有统计学意义(P=0.003)。B组生活质量改善明显高于A组,差异有统计学意义(P=0.002)。Ⅲ度~Ⅳ度肝肾功能损害、骨髓抑制及消化道反应发生率A组分别为16.2%、23.5%及25.0%;B组分别为13.2%、20.6%及30.9%,差异均无统计学意义(肝肾功能损害P=0.628;骨髓抑制P=0.679;消化道反应P=0.444)。结论热疗联合化疗治疗中晚期食管癌,疗效确切,生活质量明显改善,安全性好,值得临床进一步研究和观察。 | 郑国宝 张建国 | 2015 | 山西医药杂志2015，44，17： | 3 |
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