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| 1 | 联合检测肿瘤抗原199、肿瘤抗原242及D-二聚体对胰腺癌早期诊断的意义显示文摘目的:探讨肿瘤抗原199(CA199)、肿瘤抗原242(CA242)、D-二聚体联合检测在胰腺癌诊断中的临床意义。方法选取本溪市中心医院2009年1月~2014年12月收治的胰腺癌患者58例和2014年2~6月于体检中心体检健康成人60例分别作为胰腺癌组和对照组,两组分别采用电化学发光法进行血清CA199、CA242检测,免疫比浊法进行血浆D-二聚体检测,并比较两组试验检测结果。结果胰腺癌组血清CA199[(229.5±121.2)kU/L]、CA242[(60.2±23.9)kU/L]、血浆D-二聚体[(2.95±1.42)mg/L]水平,与对照组血清 CA199[(19.2±9.2)kU/L]、CA242[(10.9±6.5)kU/L]、血浆D-二聚体[(0.45±0.22)mg/L]比较,检测值均明显升高,差异有统计学意义(t=3.452、3.024、3.592;P=0.002、0.002、0.001)。三项联合检测(CA199+CA242+D-二聚体)的敏感度和特异度分别为95.4%和96.9%,高于任意两项联合检测及单一项检测的敏感度和特异度,差异有统计学意义(P〈0.05)。结论肿瘤抗原CA199、CA242及D-二聚体联合检测可提高胰腺癌诊断的敏感度和特异度,为临床诊断提供更为早期和准确的依据。 | 金鑫 | 2015 | 中国医药导报2015，12，19： | 7 |
| 2 | 胰腺癌靶向纳米递药系统的研究进展显示文摘胰腺癌是一种恶性程度高的消化系统肿瘤。胰腺癌临床化疗药物如吉西他滨等由于肿瘤靶向性差,在肿瘤组织浓度较低,治疗效果有限。纳米递药系统在肿瘤治疗中发挥了增效减毒作用。如何增强纳米药物对胰腺癌的靶向性并提高药物的递送效率一直是药物制剂领域的研究热点和难点。本文从靶向胰腺癌细胞、胰腺癌组织间质、胰腺癌相关细胞和胰腺癌干细胞4个方面综述了近年来纳米递药系统对胰腺癌的靶向策略,为胰腺癌的临床治疗提供参考。 | 李梦茹 李腾 莫然 | 2018 | 药学学报2018，53，7： | 6 |
| 3 | 胰腺癌早期诊断方法及临床分析(附264例报告)显示文摘分析胰腺癌的临床特点,讨胰腺癌的早期诊断方法。回顾总结264例胰腺癌患者的临床特征,统计患者的首发症状和各种检查方法的阳性例数。首发症状以上腹痛、上腹不适、黄疸多见,出现病例数分别为153例(58.0%)、44例(16.7%)、51例(19.3%)。影像学检查阳性率为BUS 80.7%、CT 84.8%、MRI 78.6%、ERCP 89.5%、EUS 79.4%、胃肠造影39.1%、DSA 90.0%。CA19-9、CA242的阳性率为83.9%、61.4%。上腹痛、上腹不适是胰腺癌最常见的首发症状;血清学肿瘤标志物对诊断早期胰腺癌的价值不大,CA19-9、CA242对胰腺癌的诊断有一定的参考价值;BUS检查是首选的最佳检查方法;对临床上怀疑胰腺癌的患者,均应行CT或MRI检查;加强健康教育,重视患者首发症状,筛查临床胰腺癌高危人群患者,选用合理检查方法,可以提高胰腺癌早期诊断率。 | 王树钢 于巍巍 费立明 | 2014 | 中国现代普通外科进展2014，17，9： | 4 |
| 4 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 5 | Is diabetes mellitus a risk factor for pancreatic cancer?显示文摘The relationship between diabetes mellitus and the risk of pancreatic cancer has been a matter of study for a long period of time.The importance of this topic is due to two main causes:the possible use of recent onset diabetes as a marker of the disease and,in particular,as a specific marker of pancreatic cancer,and the selection of a population at risk for pancreatic cancer.Thus,we decided to make an in-depth study of this topic;thus,we carried out an extensive literature search in order to re-assess the current knowledge on this topic.Even if diabetes is found a decade before the appearance of pancreatic cancer as reported in meta-analytic studies,we cannot select those patients already having non detectable pancreatic cancer,at least with the imaging and biological techniques available today.We believe that more studies are necessary in order to definitively identify diabetes mellitus as a risk factor for pancreatic cancer taking into consideration that approximately 10 years are needed to diagnose symptomatic pancreatic cancer.At present,the answer to the as to whether diabetes and pancreatic cancer comes first similar to the adage of the chicken and the egg is that diabetes is the egg. | Raffaele Pezzilli Nico Pagano | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 6 | 胰腺癌早期诊断的临床分析264例显示文摘目的:分析胰腺癌的临床特点,探讨胰腺癌的早期诊断方法。方法回顾总结我院肝胆外科2007年1月至2013年10月264例胰腺癌病人的临床特征,统计患者的首发症状和各种检查方法的阳性例数。结果首发症状以上腹痛、上腹不适、黄疸、厌食、体重减轻多见,出现病例数分别为153例(58.0%)、44例(16.7%)、51例(19.3%)、39例(14.8%)、33例(12.5%)。影像学检查阳性率为BUs 80.7%、ct84.8%、Mri78.6%、ercP89.5%、eUs79.4%、胃肠造影39.1%、dsa90.0%。ca19-9、ca242的阳性率为83.9%、61.4%。结论上腹痛、上腹不适是胰腺癌最常见的首发症状;血清学肿瘤标记物对诊断早期胰腺癌的价值不大,ca19-9、ca242对胰腺癌的诊断有一定的参考价值;BUs检查是首选的最佳检查方法;对临床上怀疑胰腺癌的患者,均应行ct或Mri检查;加强健康教育,重视患者首发症状,筛查临床胰腺癌高危人群患者,选用合理检查方法,可以提高胰腺癌早期诊断率。 | 王树钢 于巍巍 费立明 | 2014 | 世界最新医学信息文摘2014，14，13： | 1 |
| 7 | 胰腺癌的早期诊断现状及GPC-1的研究进展显示文摘胰腺癌因其早期诊断困难,就诊时已多为中晚期,病死率极高。多年来胰腺癌的早期诊断一直是医学领域的研究热点,但目前仍未寻找到最合适的早期诊断指标。本文通过复习国内外文献资料,总结对胰腺癌的早期诊断价值较高的有关指标,当前最为热门的是磷脂酰肌醇蛋白聚糖-1(GPC-1),其在胰腺癌早期诊断和筛查方面是一个很有潜力的标志物。 | 李凤飞 郭怀斌 曾凡刚 张万星 | 2019 | 肝胆胰外科杂志2019，31，5： | 0 |
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