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| 1 | γ电离辐射对斑马鱼胚胎肝、脾和肾发育形态学的影响显示文摘为研究γ电离辐射对水生生物重要器官发育形态学的影响,以斑马鱼(Danio rerio)作为模式生物,研究了胚胎发育早期(受精后5h,5hpf)接受急性γ辐照(累积剂量为0.25、0.5、1Gy,剂量率为47.79cGy/min)后,受精后3d(3dpf)的幼鱼卵黄囊面积以及3dpf和5dpf的幼鱼肝、肾和脾发育形态学的变化。结果显示:3dpf的幼鱼卵黄囊面积随剂量的增大而增大;3dpf的幼鱼肝脏中空泡增加、肝脏局部出现空洞;5dpf的幼鱼肝脏尺寸缩减、肝细胞内空泡增加且细胞核变形、血窦较小以及有核红细胞变形等;但前肾和脾的发育形态并没有出现异常。随后对3dpf的幼鱼肝细胞超微结构进行观察,发现γ辐照使幼鱼肝脏细胞线粒体受损、核膜间隙扩大、粗面内质网排列混乱等。以上结果表明,γ辐照对胚胎卵黄吸收有抑制作用,并呈一定的剂量依赖性,胚胎肝脏的发育形态在显微及亚显微结构上都发生了改变。 | 冯永富 胡南 丁德馨 赵维超 胡淼 | 2017 | 原子能科学技术2017，51，10： | 4 |
| 2 | Tissue-resident macrophages: from zebrafish to mouse显示文摘Tissue-resident macrophages(TRMs),generally found in tissues under normal physiological conditions,play crucial roles not only in immunity but also in tissue development and homeostasis.Because of their diverse functions,dysregulation of their development and function has been implicated in many human disorders.In the past decade,a great deal of extensive studies have been conducted in various model organisms with cutting-edge technologies to explore the origin and function of TRMs.In this review,we summarize the recent findings on TRMs in mouse and zebrafish and compare the similarity/differences between these two species. | Xi Lin Zilong Wen Jin Xu | 2019 | Blood Science2019，1，1： | 0 |
| 3 | Cebpa is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish显示文摘In vertebrates, myeloid cells arise from multiple waves of development: the first or embryonic wave of myelopoiesis initiates early from non-hematopoietic stem cell(HSC) precursors and gives rise to myeloid cells transiently during early development; whereas the second or adult wave of myelopoiesis emerges later from HSCs and produces myeloid cells continually during fetal and adult life. In the past decades, a great deal has been learnt about the development of myeloid cells from adult myelopoiesis, yet the genetic network governing embryonic myelopoiesis remains poorly defined. In this report, we present an in vivo study to delineate the role of Cebpa during zebrafish embryonic myelopoiesis. We show that embryonic myelopoiesis in cebpa-deficient zebrafish mutants initiates properly but fails to produce macrophages and neutrophils. The lack of macrophages and neutrophils in the mutants is largely attributed to the cell cycle arrest of embryonic myeloid progenitors, resulting in the impairment of their maintenance and subsequent differentiation. We further show that Cebpa, perhaps acting cooperatively with Runx1, plays a critical role in embryonic neutrophil maintenance. Our findings reveal a new role of Cebpa in embryonic myelopoiesis. | Yimei Dai Lu Zhu Zhibin Huang Minyu Zhou Wan Jin Wei Liu Mengchang Xu Tao Yu Yiyue Zhang Zilong Wen Wangjun Liao Wenqing Zhang | 2016 | Journal of Genetics and Genomics2016，43，10： | 0 |
| 4 | 斑马鱼髓系细胞发育显示文摘髓系生成是从造血干细胞(hematopoietic stem cell,HSCs)到成熟的髓系祖细胞的分化过程,接着再通过终端分化形成粒系和单核/巨噬系细胞(中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和巨噬细胞)[1]。髓系细胞发育异常与各种人类疾病的发生和发展相关. | 王欢 明邦发 陈柳蓉 贾海波 王雅琴 | 2022 | 发育医学电子杂志2022，10，1： | 0 |
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