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		题名	作者	年代	出处	被引量
	1	骨髓间充质干细胞向神经细胞的分化显示文摘近年来,骨髓间充质干细胞逐渐成为神经科学领域的研究热点,广泛用于治疗神经退行性疾病,其原因是;骨髓间充质干细胞可在诱导物存在下定向分化为有功能的神经元细胞,并能成功表达神经标志蛋白。结合近几年的研究进展,主要从骨髓间充质干细胞的临床试验和应用;激光辐射、氧气含量和神经细胞对骨髓间充质干细胞分化为神经细胞的影响;microRNA、Notch信号通路和Wnt信号通路对骨髓间充质干细胞分化为神经细胞的调节作用等三方面进行阐述。	安秀峰黄汉昌姜招峰	2013	生命科学2013，25，1：	8
	2	Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation显示文摘An established contribution of neuroinflammation to multiple brain pathologies has raised the requirement for therapeutic strategies to overcome it in order to prevent age-and disease-dependent cognitive decline.Mesenchymal stem cells(MSCs)produce multiple growth and neurotrophic factors and seem to evade immune rejection due to low expression of major histocompatibility complex class I molecules.Therefore,MSCs are widely used in experiments and clinical trials of regenerative medicine.This review summarizes recent data concerning the optimization of MSC use for therapeutic purposes with the emphasis on the achievements of the last 2 years.Specific attention is paid to extracellular vesicles secreted by MSCs and to the role ofα7 nicotinic acetylcholine receptors.The reviewed data demonstrate that MSCs have a significant therapeutic potential in treating neuroinflammation-related cognitive disfunctions including age-related neurodegenerative diseases.The novel data demonstrate that maximal therapeutic effect is being achieved when MSCs penetrate the brain and produce their stimulating factors in situ.Consequently,therapeutic application using MSCs should include measures to facilitate their homing to the brain,support the survival in the brain microenvironment,and stimulate the production of neurotrophic and anti-inflammatory factors.These measures include but are not limited to genetic modification of MSCs and pre-conditioning before transplantation.	Maryna Skok	2021	World Journal of Stem Cells2021，13，8：	0

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