共被期刊论文引用了3次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy显示文摘MicroRNAs (miRNAs) are widely expressed in organisms and are implicated in the regulation of most biological functions. The present study investigated the association of plasma miRNAs with the clinical outcomes of dual antiplatelet therapy in coronary artery disease (CAD) patients who underwent percutaneous coronary intervention (PCI). Plasma miRNA levels were screened using high-throughput Illumina sequencing to evaluate the antiplatelet efficacy of clopidogrel and aspirin. Six plasma miRNAs (miR-126, miR-130a, miR-27a, miR-106a, miR-21, and miR-142) were associated with clopidogrel-treated platelet aggregation. These miRNAs were validated in a prospective cohort of 1230 CAD patients using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). High plasma miR-142 levels were associated with a high risk of major adverse cardiovascular events (MACE), with a hazard ratio (95% confidence interval) of 1.83 (1.30–2.59) at a false discovery rate of <5%. Multivariable Cox regression analysis revealed that diabetes mellitus, heart failure, calcium channel blocker application, and a high plasma miR-142 level were independent risk factors of MACE. The levels of the six plasma miRNAs were not significantly associated with bleeding events during the 3-year follow-up. In conclusion, plasma miR-142 is potential marker to predict MACE in CAD patients after PCI. | Qian-jie Tang He-ping Lei Hong Wu Ji-yan Chen Chun-yu Deng Wang-sheng Sheng Yong-heng Fu Xiao-hong Li Yu-bi Lin Ya-ling Han Shi-long Zhong | 2019 | Acta Pharmacologica Sinica2019，40，2： | 6 |
| 2 | 框架核酸在活细胞分子诊断和成像中的应用显示文摘框架核酸是一类基于DNA纳米技术构建的具有特定框架结构的核酸体系.该类结构由天然核酸基于碱基互补配对原则组装,具有均一而稳定的拓扑结构、良好的生物相容性和极低的细胞毒性;框架核酸可以在无转染试剂辅助的情况下直接穿过细胞膜,有效保护所载带的生物分子长时间抵御生理环境中核酸酶的降解,为活细胞分子诊断和成像提供了新工具.文章综述了框架核酸的组装、功能化及表征方法,结合其结构特点介绍了框架核酸在活细胞分子诊断和成像中的应用,包括活细胞核酸标志物、离子、其他生物分子及循环肿瘤细胞的检测与成像,并分析了其发展应用前景,为框架核酸在活细胞诊断相关领域的研究提供了新的思路和研究依据. | 朱丹 张成文 王子纯 晁洁 | 2020 | 广州大学学报(自然科学版)2020，19，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员