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| 1 | 质子泵抑制剂和阿莫西林双联方案在幽门螺杆菌感染根除治疗中的应用显示文摘幽门螺杆菌感染及其相关疾病是全球重要卫生健康问题,临床上大量患者需进行根除治疗。然而,随着常用抗生素耐药率的明显升高,现有根除方案疗效显著下降,根除治疗形势日趋严峻,亟需开发安全、高效、可广泛应用的新方案。近期,4次/d口服的质子泵抑制剂和阿莫西林双联方案以其良好的疗效、安全性和依从性受到国内外学者的广泛关注。本文对其历史、作用机制、研究现状、优缺点等进行了综述,有利于指导未来相关研究和临床应用。 | 李彩玲 宋志强 索宝军 石岩岩 周丽雅 | 2021 | 中华医学杂志2021，101，10： | 11 |
| 2 | 阿莫西林与质子泵抑制剂大剂量二联疗法根除幽门螺杆菌的研究进展显示文摘幽门螺杆菌(Helicobacter pylori,HP)感染在世界范围普遍高发,国内外指南推荐的一线根除方案在实际应用中面临许多挑战。为进一步提高HP根除率及患者依从性,抗生素耐药增加、服药种类繁多及药物副作用明显等问题亟待解决。近年来,由阿莫西林联合质子泵抑制剂的大剂量二联疗法治疗HP感染取得了较好的根除效果。该文通过对大剂量二联疗法的作用机制、安全性及治疗效果进行综述,旨在为临床诊疗提供参考。 | 郑旭林 余欣鑫 陈拥军 | 2022 | 华西医学2022，37，9： | 2 |
| 3 | Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection显示文摘We have previously reported that Helicobacter pylori(H.pylori)-associated nodular gastritis could occur in both the antrum and the cardia.Cardiac nodularity-like appearance(hereafter,called as cardiac nodularity)had a high predictive accuracy for the diagnosis of H.pylori infection.In the previous study,we included only the patients who were evaluated for H.pylori infection for therst time,and excluded patients with a history of eradication.Therefore,the prevalence and clinical features of cardiac nodularity remains unknown.AIM To perform this cross-sectional study to explore the characteristics of cardiac nodularity.METHODS Consecutive patients who underwent esophagogastroduodenoscopy betweenMay,2017 and August,2019 in the Toyoshima Endoscopy Clinic were enrolled in this study.We included H.pylori-negative,H.pylori-positive,and H.pylorieradicated patients,and excluded patients with unclear H.pylori status and eradication failure.H.pylori infection was diagnosed according to serum anti-H.pylori antibody and the urea breath test or histology.Cardiac nodularity was defined as a miliary nodular appearance or the presence of scattered whitish circular small colorations within 2 cm of the esophagogastric junction.Nodularity was visualized as whitish in the narrow-band imaging mode.We collected data on the patients’baseline characteristics.RESULTS A total of 1078 patients were finally included.Among H.pylori-negative patients,cardiac nodularity and antral nodularity were recognized in 0.14%each.Among H.pylori-positive patients,cardiac nodularity and antral nodularity were recognized in 54.5%and 29.5%,respectively.Among H.pylori-eradicated patients,cardiac nodularity and antral nodularity were recognized in 4.5%and 0.6%,respectively.The frequency of cardiac nodularity was significantly higher than that of antral nodularity in H.pylori-positive and-eradicated patients.The frequencies of cardiac nodularity and antral nodularity in H.pylori-eradicated patients were significantly lower than those in H.pylori-positive patients(P<0.001).The patients with cardiac nodularity were significantly younger than those without cardiac nodularity(P=0.0013).Intestinal metaplasia score of the patients with cardiac nodularity were significantly lower than those without cardiac nodularity(P=0.0216).Among H.pylori-eradicated patients,the patients with cardiac nodularity underwent eradication significantly more recently compared with those without cardiac nodularity(P<0.0001).CONCLUSION This report outlines the prevalence and clinical features of cardiac nodularity,and confirm its close association with active H.pylori infection. | Toshihiro Nishizawa Kosuke Sakitani Hidekazu Suzuki Shuntaro Yoshida Yosuke Kataoka Yousuke Nakai Hirotoshi Ebinuma Takanori Kanai Osamu Toyoshima Kazuhiko Koike | 2020 | World Journal of Gastroenterology2020，26，35： | 1 |
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