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| 1 | How does the motor relearning program improve neurological function of brain ischemia monkeys?显示文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. | Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng | 2013 | Neural Regeneration Research2013，8，16： | 9 |
| 2 | 缺血性脑卒中非人灵长类动物模型研究进展显示文摘缺血性脑卒中因其高发病率、致残率和致死率,造成了严重的疾病负担,是医药研发人员关注的重点疾病之一。但脑卒中临床前研究结果向临床转化率低,凸显了对动物模型优化的迫切需要。非人灵长类动物(nonhuman primates,NHPs)在大脑解剖和生理学方面与人类相似性更高,因此,利用NHPs构建模型,有望促进缺血性脑卒中临床前研究向临床治疗的转化。本文对脑卒中NHPs模型的建模方法和评价指标以及模型应用进展进行综述,讨论近期所用模型及评价方法的优势和不足,并对未来NHPs模型研究需要克服的困难和可能的发展方向进行了展望。 | 孙宇航 管博文 魏强 孟爱民 | 2022 | 中国比较医学杂志2022，32，8： | 2 |
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