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| 1 | 炎性肠病术后并发症危险因素及预防的专家意见(2014·广州)显示文摘炎性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),近年来在我国发病呈明显上升趋势。这些年来,我国医务工作者对IBD的临床和研究进行了大量卓有成效的工作,诊疗水平已大大提高,2012年我国炎症性肠病学组发表了内容详尽的IBD诊断和治疗的共识意见[1]。但是,该共识意见主要着重于内科治疗的论述。随着我国IBD患者的增加以及病程的延长,需要接受外科手术治疗的患者亦日渐增多,IBD的手术问题已成为我国当前必须面对的重要问题。 | 兰平 胡品津 朱维铭 | 2015 | 中华胃肠外科杂志2015，18，4： | 24 |
| 2 | Helicobacter pylori and Crohn's disease: A retrospective single-center study from China显示文摘AIM: To investigate the association between Helicobacter pylori (H. pylori ) infection and the prevalence of Crohn's disease (CD). METHODS: Subjects were selected from patients admitted the gastrointestinal (GI) department at The First Affiliated Hospital School of Medicine (Zhejiang University)for abdominal pain, hematochezia, diarrhea and other GI symptoms between January 2008 and September 2012. CD was diagnosed by endoscopy and biopsy. H. pylori infection was detected by a 14 C-urea breath test and culturing of the biopsy sample. Demographic, anthropometric and serologic data were collected for each patient. H. pylori infection rate was compared between CD and control groups, followed by a subgroup analysis based on extent and severity of CD. Student's t , Mann-Whiney U , and χ 2 tests were used to analyze the data. RESULTS: A total of 447 patients were analyzed, including 229 in the CD group and 248 in the control group. There were no significant differences in age, sex, and rates of hypertension or diabetes. However, the CD group showed significantly higher rates of smoking history (34.9% vs 18.1%), alcohol intake (17.4% vs 8.1%), white blood cell count (9.7 ± 2.9 × 10 9 /L vs 4.3 ± 0.9 × 10 9 /L), and C-reactive protein (36.3 ± 20.8 mg/L vs 5.5 ± 2.3 mg/L) but lower body mass index (24.5 ± 2.0 kg/m 2 vs 26.0 ± 2.2 kg/m 2 ) than the control group. The H. pylori infection rate in the CD group was 27.1%, significantly lower than that of 47.9% in the control group. Furthermore, the H. pylori infection rates in patients with colonic, small intestine, ileocolonic and extensive CD were 31.1%, 28.9%, 26.8% and 25.9% respectively, all of which were significantly lower than in the control group. Finally, the H. pylori infection rates in patients with remission, moderate and severe CD were 34.3%, 30.7% and 22.0% respectively, which were also significantly lower than in the control group. CONCLUSION: Lower H. pylori infection in CD patients suggests a correlation between bacterial infection and CD, suggesting caution when considering H. pylori eradication in CD patients. | Zun Xiang Yi-Peng Chen Yue-Fang Ye Kui-Fen Ma Shao-Hua Chen Lin Zheng Yi-Da Yang Xi Jin | 2013 | World Journal of Gastroenterology2013，19，28： | 9 |
| 3 | Similarities and differences between Behet's disease and Crohn's disease显示文摘Behet's disease(BD) is a chronic inflammatory condition with multisystem involvement. Approximately 10%-15% of patients present with gastrointestinal involvement. Involved sites and the endoscopic view usually resemble Crohn's disease(CD). In addition to intestinal involvement, oral mucosa, the eyes, skin, and joints are commonly affected. No pathognomonic laboratory test is available for the diagnosis of either disease. Management approaches are also similar in various aspects. Differentiating BD from CD is highly challenging. In this article, the similarities and differences between BD and CD in terms of epidemiology, etiopathogenesis, clinical and imaging findings, and histopathological and therapeutic approaches are reviewed. | Veli Yazsz | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 4 |
| 4 | 治疗克罗恩病的非生物制剂疗效比较:基于网状Meta分析的比较结果显示文摘目的系统评价不同非生物制剂治疗成人克罗恩病患者的疗效和安全性。方法计算机检索Pubmed、The Cochrane library、中国期刊全文数据库和万方数据知识服务平台数据库,搜集不同非生物制剂治疗成人克罗恩病患者的随机对照研究,检索时限均为建库至2021年7月。两位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R3.6.1软件gemtc程序包进行贝叶斯网状Meta分析。结果共纳入21个研究,针对疗效指标诱导期缓解率的网状Meta分析结果显示:与安慰剂相比,6-巯基嘌呤、硫唑嘌呤、布地奈德、柳氮磺吡啶联用6-巯基嘌呤能显著提高诱导期缓解率。对于这10种干预措施排序可知,6-巯基嘌呤疗效最好的概率最大,奥沙拉嗪的概率最小。针对疗效指标维持期缓解率的网状Meta分析结果显示:与安慰剂相比,硫唑嘌呤能显著提高维持期缓解率。针对安全性指标依从性的网状Meta分析结果显示:与安慰剂相比,纳入的所有干预措施的依从性与安慰剂比较均无显著差异。对于这8种干预措施排序可知:依维莫司的依从性最好的概率最大,甲氨蝶呤的概率最小。结论现有证据表明,在成人克罗恩病的非生物制剂治疗中,6-巯基嘌呤在诱导期缓解效果更好,硫唑嘌呤在维持期缓解效果更好,而就依从性而言纳入的各干预措施无较大差别。 | 王樱澄 芮明军 费正洋 马爱霞 | 2023 | 中国药物经济学2023，18，1： | 0 |
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