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| 1 | 奥沙拉秦联合微生态制剂对溃疡性结肠炎的治疗显示文摘目的探讨奥沙拉秦联合微生态制剂治疗溃疡性结肠炎的临床疗效。方法将2008年6月~2011年6月收治的92例溃疡性结肠炎患者随机分成两组,对照组46例单纯给予奥沙拉秦治疗,治疗组46例在对照组治疗的基础上加用微生态制剂,两组疗程均为4周。结果治疗组的总有效率为91.3%,对照组的总有效率为76.1%,两组相比较有显著性差异(P<0.05)。结论奥沙拉秦联合微生态制剂治疗溃疡性结肠炎疗效确切,不良反应较少,患者易于接受,值得临床推广应用。 | 张勤生 | 2012 | 当代医学2012，18，23： | 11 |
| 2 | 美沙拉嗪联合三联活菌微生态制剂治疗轻中度溃疡性结肠炎的效果观察显示文摘目的探讨美沙拉嗪联合三联活菌微生态制剂治疗轻中度溃疡性结肠炎的临床效果。方法选取2013-06~2016-02该院消化内科治疗的轻中度溃疡性结肠炎患者90例,随机分为研究组和对照组,各45例。研究组采用美沙拉嗪联合三联活菌微生态制剂治疗,对照组仅采用美沙拉嗪治疗。均治疗8周,观察两组的疗效、不良反应等情况。结果研究组显效24例,有效18例,无效3例。对照组显效13例,有效19例,无效13例,研究组疗效优于对照组(P<0.01)。治疗前研究组与对照组疾病活动指数(DAI)评分、肠镜积分、临床症状评分比较差异均无统计学意义(P>0.05)。治疗后研究组与对照组患者DAI评分、肠镜积分及临床症状评分均较治疗前降低,但研究组降低更明显,治疗后组间比较差异有统计学意义(P<0.01)。研究组的不良反应率(4.44%)低于对照组(6.67%),但差异无统计学意义(P>0.05)。结论对轻中度溃疡性结肠炎患者采用美沙拉嗪联合三联活菌微生态制剂进行治疗,可以增强治疗效果,同时不会增加药物的不良反应发生率,值得推广应用。 | 杨蔚峰 班洁虹 饶官华 庞美志 邹尤宝 | 2017 | 中国临床新医学2017，10，6： | 9 |
| 3 | Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?显示文摘Ulcerative colitis(UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic inflammation. Current evidence suggests that presence of histological inflammation poses a greater risk of disease relapse and subsequent colorectal cancer risk. New endoscopic technologies hold promise for developing endoscopic markers of mucosal inflammation. Achieving endoscopic and histological remission appears be the future aim of medical treatments for UC. This review article aims to evaluate the use of endoscopy as a tool in assessment of mucosal inflammation UC and its correlation with disease outcomes. | Noor Mohammed Venkataraman Subramanian | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 4 | Autofluorescence imaging endoscopy can distinguish non-erosive reflux disease from functional heartburn: A pilot study显示文摘AIM: To investigate whether autofluorescence imaging(Af I) endoscopy can distinguish non-erosive reflux disease(NERD) from functional heartburn(fh).METHODS: In this prospective observational trial, 127 patients presenting with typical reflux symptoms for > 6 mo were screened. All the participants underwent endoscopy, during which white light imaging(WLI) was followed by Af I. finally 84 patients with normal esophageal appearance on WLI were enrolled. It was defined as being suggestive of NERD if one or more longitudinal purple lines longer than one centimeter were visualized in the distal part of the esophagus during Af I endoscopy. Ambulatory 24-h multichannel intraluminal impedance and ph monitoring was also performed. After standard proton-pump inhibitor(PPI) tests, subjects were divided into an NERD group and an fh group and the diagnostic performance of Af I endoscopy to differentiate NERD from fh was evaluated.RESULTS: Of 84 endoscopy-negative patients, 36(42.9%) had a normal ph/impedance test. Of these, 26 patients with favorable responses to PPI tests were classified as having NERD. finally 10 patients were diagnosed with fh and the others with NERD. Altogether, 68(81.0%) of the 84 patients were positive on Af I endoscopy. In the NERD group, there were 67(90.5%) patients with abnormal esophageal findings on Af I endoscopy while only 1(10%) patient was positive on Af I endoscopy in the fh group. The sensitivity and specificity of AFI in differentiating NERD from FH were 90.5%(95%CI: 81.5%-96.1%) and 90.0%(95%CI: 55.5%-99.7%), respectively. Meanwhile, the accuracy, positive predictive value and negative predictive value of Af I in differentiating between NERD and fh were 90.5%(95%CI: 84.2%-96.8%), 98.5%(95%CI: 92.1%-99.9%) and 56.3%(95%CI: 30.0%-80.2%), respectively.CONCLUSION: Autofluorescence imaging may serve as a complementary method in evaluating patients with NERD and fh. | Xi Luo Xiao-Xu Guo Wei-feng Wang Li-hua Peng Yun-sheng Yang Noriya Uedo | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 5 | "止痢颗粒"治疗溃疡性结肠炎的临床疗效观察显示文摘目的 探讨"止痢颗粒"治疗溃疡性结肠炎的临床疗效.方法 选取2015年8月至2016年8月本院消化内科就诊的溃疡性结肠炎患者80例为研究对象,随机分为对照组40例,观察组40例;对照组患者给予溃疡性结肠炎常规治疗,观察组患者在常规治疗的基础上加用"止痢颗粒"3d.观察两组患者的临床疗效,并比较分析.结果 观察组总有效率明显高于对照组总有效率,差异有统计学意义(P〈0.05);观察组症状改善情况明显优于对照组,差异有统计学意义(P〈0.05).结论 溃疡性结肠炎患者在常规治疗的基础上给予"止痢颗粒"治疗,疗效确切,能够显著改善腹痛、腹泻及黏液血便等症状,可以在临床上推广使用. | 刘金岩 曾晓红 雷莉 | 2017 | 检验医学与临床2017，14，A02： | 0 |
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