共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties显示文摘寻找新奇 anticancer 代理人,包含 1,3,4-thiadiazole 一半的一系列 N 甲基 colchiceinamide 衍生物(7a7i ) 被综合,并且他们的结构被证实由光谱分析。这些混合物的 Cytotoxicity 被 MTT 试金与四根人的肿瘤房间线在 vitro 作比较,即 A2780, A549, BEL7402,和 MCF-7。结果显示特别地,大多数衍生物显示出重要 anticancer 活动混合物 7h 和 7i 显示出更多的有势力所有屏蔽癌症房间的细胞毒素的活动比用番红花作原料而制成的植物盐基。 | Li-Hong Shen Hong-Yu Li Hui-Xia Shang Shu-Ting Tian Yi-Sheng Lai Li-Jie Liu | 2013 | Chinese Chemical Letters2013，24，4： | 7 |
| 2 | Novel synthetic acridine-based derivatives as topoisomerase Ⅰ inhibitors显示文摘Novel DNA binding agents against topoisomerases are needed for effective treatment of cancers. A series of new acridine-based derivatives 7a–7d were synthesized and their antiproliferative activity against K562 and HepG-2 cell lines were evaluated. Compound 7c with pyridin-2-yl-methanamino group substituted at the C9 position of acridine showed good antitumor activity against both cell lines. The DNA-binding affinity of compound 7c was evaluated by UV–vis absorption spectra and fluorescence emission spectra. DNA topoisomerase I mediated relaxation of plasmid pBR322 DNA was also tested. Our results suggested that compound 7c with good antitumor activity and topoisomerase I inhibition activity can be developed as a prime candidate for further chemical optimization. | Bin Li Chun-Mei Gao Qin-Sheng Sun Lu-Lu Li Chun-Yan Tan Hong-Xia Liu Yu-Yang Jiang | 2014 | Chinese Chemical Letters2014，25，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员