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| 1 | PNPLA3、TM6SF2基因多态性及其与吸烟、饮酒交互作用对HBV相关肝癌的影响显示文摘目的探讨PNPLA3、TM6SF2基因多态性及其与吸烟、饮酒交互作用对HBV相关肝癌(hepatitis B virus—associated hepatocellular carcinoma,HBV-HCC)的影响。方法收集2010年1月至2014年3月HBV-HCC患者、慢性乙型肝炎(乙肝)患者(CHB)、肝硬化患者(LC)以及健康体检者的血液标本,应用飞行质谱技术检测patatin样磷脂酶域3(PNPLA3)基因位点rs738409和6号跨膜超家族成员2(TM6sF2)基因位点rs58542926的单核苷酸多态性(SNP)。利用在线SNP stats寻找基因多态性的最优赋值方法;检验SNP是否符合哈一温(H-W)遗传平衡定律;采用多分类logistic回归分析PNPLA3和TM6SF2多态性及吸烟、饮酒因素对HBV-HCC的影响,采用叉生分析和二分类logistic回归分析探讨基因一基因、基因一吸烟、饮酒交互作用对HBV-HCC的影响。结果H—W遗传平衡检验结果显示,CHB组rs738409位点的基因型频率分布不符合H—W遗传平衡定律(Χ^2=11.980,P<0.005),CHB组rs58542926位点、HBV-HCC组和LC组rs738409和rs58542926位点均符合H-W遗传平衡定律;调整年龄、性别的影响后,与健康体检者相比,HBV-HCC组rs58542926突变的OR=1.659,95%CI:1.026~2.684,P=0.039。与CHB组相比,HBV-HCC组饮酒的OR=1.680,95%CI:1.121~2.519,P=0.012。与LC组相比,HBV-HCC组饮酒与吸烟的OR值(95%CI)分别为1.539(1.071~2.213)和1.453(1.005~2.099)。交互作用分析显示,HBV-HCC组与CHB+LC组相比,rs738409与rs58542926交互作用的叉生分析相加模型OR=1.548(u=1.885,P=0.029),logistic回归相乘模型OR=1.658(P=0.024);饮酒与rs738409的交互作用叉生分析,饮酒且rs738409突变相加模型OR=1.811(U=1.965,P=0.024),相乘模型无统计学意义;logistic回归相乘模型吸烟与饮酒的交互作用OR=1.756(P<0.001)。结论TM6SF2基因突变、吸烟、饮酒是HBV-HCC的危险因素,PNPLA3与TM6SF2基因都突变、饮酒并且吸烟是HBV-HCC的危险因素。PNPLA3的单基因突变可以减弱饮酒对HBV-HCC的危害。 | 王立芹 郭维恒 郭志旺 秦璞 张蕊 朱晓敏 刘殿武 | 2018 | 中华流行病学杂志2018，39，12： | 17 |
| 2 | Comparison of the clinical characteristics and survival between Uyghur patients with hepatitis virus-related and non-B, non-C hepatocellular carcinoma in Xinjiang, China显示文摘Objective: To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma(viral HCC) and non-B, non-C HCC(NBC-HCC) among Uyghur patients in Xinjiang province, China. Methods: Between 01/01/2000 and 31/12/2012, 319 Uyghur HCC patients were treated at the Cancer Centre of The First Affiliated Hospital of Xinjiang Medical University. The data for the patients were obtained from a retrospective review of the patients' medical records. A total of 18 patients were excluded from the study because of incomplete information. The patients were classified into two groups: viral HCC and NBC-HCC. The clinical characteristics and prognostic factors were statistically analysed.Results: For all 301 patients, gender(P=0.000), area of residence(P=0.002), diabetes mellitus(P=0.009), BMI(P=0.000), cirrhosis(P=0.000), tumour stage(P=0.004), Child-Pugh class(P=0.000), the TBIL level(P=0.000), and the alpha-fetoprotein(AFP) level(P=0.000) were significantly different between the NBC-HCC and viral HCC groups. The NBC-HCC patients tended to be diagnosed at advanced stages; however, the NBC-HCC patients exhibited lower Child-Pugh scores than the viral HCC patients. In all patients examined, the 0.5-, 1-, 3- and 5-year overall survival(OS) rates were 35.6%, 20.3%, 12.6% and 4.5%, respectively. No significant difference in OS was observed between the two groups(P=0.124). Cox multivariate analysis revealed that age(RR =1.539, P=0.001), TNM stage(RR =12.708, P=0.000), portal vein tumour thrombus(PVTT)(RR =2.003, P=0.000), Child-Pugh class(RR =1.715, P=0.000), and TACE + radiotherapy/RFA(RR =0.567, P=0.000) were significant independent prognostic factors for HCC patients. Conclusions: The clinical characteristics differ between Uyghur patients with NBC-HCC and viral HCC. HCC in the Xinjiang region displays specific regional characteristics. Age, TNM stage, PVTT, Child-Pugh class and TACE + radiotherapy/RFA are significant risk factors that influence patient survival. | Lei Xiao Rui-Li Zhang Hua Zhang Aisiker Tulahong Yue-Fen Zhang Hao Wen Yong-Xing Bao | 2015 | Chinese Journal of Cancer Research2015，27，3： | 10 |
| 3 | 2011-2016年哈尔滨市乙肝流行特征分析显示文摘目的分析哈尔滨市2011-2016年乙肝报告发病现状,评价乙肝防控效果,为哈尔滨市有效控制乙肝发病提供建议。方法利用2011-2016年《中国疾病预防控制信息系统》中《传染病报告信息管理系统》中乙肝报告发病数据,运用描述流行病学方法比较不同地区、年龄、职业等发病情况。结果 2011-2016年,哈尔滨市乙肝发病率由2011年的30.85/10万下降到2016年的24.87/10万;发病率最高的年龄组为60岁^(36.14/10万),其次为30岁^(34.51/10万)、25岁^(34.36/10万);男性/女性全部/急性乙肝平均发病率分别为30.35/10万、22.53/10万和5.62/10万、3.15/10万,均呈现为男性均高于女性;农民、家务及待业、工人病例居前3位,分别占总病例数的60.55%、20.33%和4.04%;高发地区为延寿县、五常市、木兰县,平均发病率分别为81.58/10万、70.36/10万和65.89/10万;2011-2016年未分类乙肝病例占比逐年降低,慢性乙肝占比逐年增加,急性乙肝占比呈现上升趋势。结论 2011-2016年哈尔滨市乙肝发病整体呈现下降趋势,特别是20岁以下人群防控措施效果明显;需要加强成年人乙肝防控工作,特别是薄弱地区和重点人群。 | 范晨璐 李玺琨 姜立坤 张欣 张在宏 刘木子 李岩 | 2020 | 现代预防医学2020，47，8： | 10 |
| 4 | Interaction between hepatitis C virus and metabolic factors显示文摘Hepatitis C virus(HCV)infection disrupts the normal metabolism processes,but is also influenced by several of the host’s metabolic factors.An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues.Substantial research efforts have been put forth recently to elucidate the molecular mechanism of HCV-induced insulin resistance,and several cytokines,such as tumor necrosis factor-α,have been identified as important contributors to the development of insulin resistance in the distant peripheral tissues of HCV-infected patients and animal models.The demonstrated etiologies of HCV-induced whole-body insulin resistance include oxidative stress,lipid metabolism abnormalities,hepatic steatosis and iron overload.In addition,myriad effects of this condition have been characterized,including glucose intolerance,resistance to antiviral therapy,progression of hepatic fibrosis,development of hepatocellular carcinoma,and general decrease in quality of life.Metabolic-related conditions and disorders,such as visceral obesity and diabetes mellitus,have been shown to synergistically enhance HCV-induced metabolic disturbance,and are associated with worse prognosis.Yet,the molecular interactions between HCV-induced metabolic disturbance and hostassociated metabolic factors remain largely unknown.The diet and lifestyle recommendations for chronic hepatitis C are basically the same as those for obesity,diabetes,and metabolic syndrome.Specifically,patients are suggested to restrict their dietary iron intake,abstain from alcohol and tobacco,and increase their intake of green tea and coffee(to attain the beneficial effects of caffeine and polyphenols).While successful clinical management of HCV-infected patients with metabolic disorders has also been achieved with some antidiabetic(i.e.,metformin)and anti-lipid(i.e.,statins)medications,it is recommended that sulfonylurea and insulin be avoided. | Yasunori Kawaguchi Toshihiko Mizuta | 2014 | World Journal of Gastroenterology2014，20，11： | 3 |
| 5 | 新疆维吾尔族非乙非丙型及病毒相关性肝癌的临床特征及预后显示文摘目的探讨新疆维吾尔族肝细胞癌(HCC)患者的临床特征和预后。方法回顾性分析301例维吾尔族HCC患者的临床资料,分为非乙型非丙型肝癌组(NBC—HCC组)和病毒相关肝癌组(viral—HCC组)。采用Kaplan-Meier法计算生存率,采用Logrank检验对影响患者预后的因素进行单因素分析,采用Cox多因素对影响患者预后的因素进行多因素分析。结果NBC—HCC组患者的性别、城乡地区、糖尿病史、体质指数、肝硬化史、临床分期、Child-pugh分级、总胆红素和甲胎蛋白水平与viral—HCC组比较,差异均有统计学意义(均P〈0.05)。全组HCC患者的1、2、3、5年生存率分别为35.6%、20.3%、12.6%和4.5%;NBC—HCC组患者的1、2、3、5年生存率分别为32.2%、18.5%、14.7%和5.2%,viral-HCC组患者的1、2、3、5年生存率分别为38.0%、21.1%、13.5%和4.1%,差异无统计学意义(P=0.124)。多因素分析结果显示,年龄、临床分期、门静脉癌栓(PVTT)、Child—push分级、肝动脉化疗栓塞(TACE)联合放疗或射频消融(RFA)均为影响HCC患者预后的独立因素(均P〈0.05)。结论NBC-HCC组和viral—HCC组肝癌患者的临床特征不尽相同,具有一定的区域特点。年龄、临床分期、PVTT、Child-pugh分级、TACE联合放疗或RFA为影响HCC患者预后的独立因素。 | 张瑞丽 周莎莎 肖蕾 张华 艾斯克尔·吐拉洪 张月芬 温浩 包永星 | 2015 | 中华肿瘤杂志2015，37，7： | 1 |
| 6 | 2012—2021年张掖市乙型病毒性肝炎监测分析显示文摘目的 分析2012—2021年甘肃省张掖市乙型病毒性肝炎(简称乙肝)流行病学特征,为乙肝防控提供依据。方法 运用描述流行病学方法分析乙肝流行病学特征,以Joinpoint回归模型分析乙肝发病率变化趋势。结果2012—2021年张掖市累计报告乙肝4 204例,年均发病率34.38/10万,发病率整体有所下降(AAPC=-1.90%);男性年均发病率高于女性,差异有统计学意义(χ^(2)=270.600,P<0.05),发病率随年龄增长呈上升趋势(趋势χ^(2)=1 438.930,P<0.05),60岁~组年均发病率最高(59.20/10万),职业以农牧民为主(占80.52%);高台县发病率最高(61.79/10万)。结论2012—2021年张掖市乙肝发病率整体有所下降,但目前仍是危害张掖市社会劳动力身体健康的重要因素;应继续开展新生儿乙肝疫苗接种,同时大力推广成年人疫苗接种,继续做好健康教育,加强医务人员乙肝诊断及报告培训。 | 肖莉 王路军 | 2023 | 疾病预防控制通报2023，38，1： | 0 |
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