|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Physical stimulations and their osteogenesis-inducing mechanisms显示文摘Physical stimulations such as magnetic,electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways,modulating ion channels,regulating bonerelated gene expressions,etc.In this paper,bioeffects of physical stimulations on cell activity,tissue growth and bone healing were systematically summarized,which especially focused on their osteogenesis-inducing mechanisms.Detailedly,magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions,especially accelerating the extracellular calcium ions to pass through cell membrane.Electric stimulation could induce inverse piezoelectric effect which generated electric signals,accordingly up-regulating intracellular calcium levels and growth factor synthesis.And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals,thus activating various signaling pathways on cell membrane and inducing a series of gene expressions.Besides,bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed.The equipments of physical stimulation system were described.The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair. | Cijun Shuai Wenjing Yang Shuping Peng Chengde Gao Wang Guo Yuxiao Lai Pei Feng | 2018 | International Journal of Bioprinting2018，4，2： | 3 |
| 2 | Biomechanics and mechanobiology of the bone matrix显示文摘The bone matrix plays an indispensable role in the human body,and its unique biomechanical and mechanobiological properties have received much attention.The bone matrix has unique mechanical anisotropy and exhibits both strong toughness and high strength.These mechanical properties are closely associated with human life activities and correspond to the function of bone in the human body.None of the mechanical properties exhibited by the bone matrix is independent of its composition and structure.Studies on the biomechanics of the bone matrix can provide a reference for the preparation of more applicable bone substitute implants,bone biomimetic materials and scaffolds for bone tissue repair in humans,as well as for biomimetic applications in other fields.In providing mechanical support to the human body,bone is constantly exposed to mechanical stimuli.Through the study of the mechanobiology of the bone matrix,the response mechanism of the bone matrix to its surrounding mechanical environment can be elucidated and used for the health maintenance of bone tissue and defect regeneration.This paper summarizes the biomechanical properties of the bone matrix and their biological significance,discusses the compositional and structural basis by which the bone matrix is capable of exhibiting these mechanical properties,and studies the effects of mechanical stimuli,especially fluid shear stress,on the components of the bone matrix,cells and their interactions.The problems that occur with regard to the biomechanics and mechanobiology of the bone matrix and the corresponding challenges that may need to be faced in the future are also described. | Chunyang Ma Tianming Du Xufeng Niu Yubo Fan | 2022 | Bone Research2022，10，4： | 2 |
| 3 | 骨细胞微环境仿生模拟技术显示文摘骨细胞是生长于骨组织中的重要功能性细胞,承载着力学感知、骨重建平衡、机体矿物质代谢和内稳态调节等多种重要功能.骨陷窝-骨小管网络系统为骨细胞生长和功能发挥提供了稳定的结构微环境,骨基质的主要成分Ⅰ型胶原蛋白和羟基磷灰石是骨细胞黏附、细胞与细胞以及细胞与细胞外基质相互作用的生化微环境基础.而骨细胞多种生理功能的发挥离不开其对周围力学微环境变化的感知与响应.此外,骨细胞对周围环境非常敏感,微环境结构、生化组成和力学刺激的变化会对骨细胞结构和功能产生较大影响.因此,在微环境基础上研究骨细胞的结构和功能,是阐明骨细胞力学感知机制、发现骨细胞新的生物学功能的前提.然而,骨陷窝-骨小管网络系统复杂的结构和坚硬的质地,给在体研究带来了很大的困难.体外构建骨细胞仿生微环境成为骨细胞结构功能研究的必经之路.本文系统介绍了骨细胞的结构、生化和力学微环境,回顾了体外骨细胞微环境仿生模拟技术的最新进展,旨在为骨基础生物学、组织工程和再生医学的发展提供参考. | 任丽 续惠云 骞爱荣 商澎 | 2014 | 生物化学与生物物理进展2014，41，11： | 1 |
| 4 | 骨内微管中流动电位的实验研究显示文摘力学载荷是骨量和结构的重要调节因素,骨重建与骨的形成和代谢密切相关。研究认为骨的力电性质是骨重建与力学载荷之间的纽带,而骨的力电性质中一个重要的研究方向就是流动电位。此研究的目的在于通过实验确定缓冲液流经哈佛氏管与骨小管时所产生的流动电位的差别。选取8个样本,使用自行设计的测试系统,测量5种不同加载速率下骨试样的流动电位。将骨试样的侧表面由硅橡胶密封,模拟缓冲液主要通过哈佛氏管流动的情形;而未密封的情况,则模拟缓冲液同时流经哈佛氏管以及试样表面上被剖开的骨单元中骨小管的情形。结果显示,对应于加载速率26、36、60、180、360 kPa/s,侧表面密封时,流动电位稳定值分别为(0.29±0.09)、(0.24±0.06)、(0.21±0.05)、(0.19±0.05)、(0.16±0.04)mV;侧表面未密封时,流动电位稳定值分别为(0.69±0.08)、(0.61±0.09)、(0.57±0.07)、(0.51±0.05)、(0.46±0.05)mV。未密封时流动电位明显高于密封时的流动电位(P值均小于0.05),而且两者的电位差反映了缓冲液流经骨小管时所产生的流动电位要明显高于流经哈佛氏管的时候。基于骨的微观结构,并考虑到骨细胞主要分布在骨小管附近,实验结果为研究流动电位与骨的重建问题提供了依据。 | 王轶涵 徐莲云 富东慧 侯振德 | 2013 | 中国生物医学工程学报2013，32，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员