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| 1 | 阴道用壬苯醇醚即型凝胶的制备与评价显示文摘目的制备以泊洛沙姆为基质的温度敏感型阴道用壬苯醇醚即型凝胶,并评价其流变学性能与体内滞留能力。方法利用倒置试管法测定胶凝温度,通过单因素实验考察泊洛沙姆与药物浓度对胶凝温度的影响。以相位角变化表征凝胶的相变过程,分别测试在模拟的储存、运输和使用状态下凝胶的流变学性质,并考察阴道模拟液稀释对凝胶相转变过程的影响。使用近红外荧光探针标记凝胶。小动物活体成像评价凝胶在小鼠体内的滞留能力。结果通过处方优化制得的凝胶其胶凝温度为(31.5±2)℃,相转变过程在3~4℃内完成,使用黏度(6.50Pa·s)〉储存黏度(1.023Pa·s)〉运输黏度(0.291Pa·s),且经阴道模拟液稀释后在体温条件下能形成凝胶。该凝胶在小鼠阴道内滞留时间长达4h。结论该凝胶的胶凝温度适宜,流变学性质良好,在阴道内滞留时间较长,满足阴道用药的要求。 | 杨富金 陈凌云 俸灵林 魏刚 陆伟跃 | 2014 | 中国药学杂志2014，49，22： | 1 |
| 2 | Reversible Antifertility Activity of Hydroalcoholic Extract of Ficus Racemosa L. in Male Mice显示文摘Objective To evaluate male antifertility activity of hydroalcoholic extract of Ficus racemosa bark. Methods Swiss male mice were orally administered hydroalcoholic extract of Ficus racemosa bark (50 mg/kg for 30 d and 100 mg/kg body weight for next 30 d), and the effect of the treatment on body weight, reproductive organs weight, sperm, biochemical profile (sialic acid in epididymis and fructose in seminal vesicle), fertility and vaginal contraceptive efficacy was investigated. Recovery studies were also performed. Results Extract reduced fertility to 70% within 60 d. Suppression of cauda epididymis sperm count, motility, viability and abnormal morphology was observed. Marked reduction was noted in the weight of reproductive organs and the level of sialic acid in epididymis and fructose in seminal vesicle. Vaginal application of bark extract exhibited 80% vaginal contraceptive efficacy. After cessation of plant extract treatment, the altered parameters recovered after 60 d. Conclusion Clinical assessment of male antifertility agents should include acceptability, safety and efficacy during and after the treatment. The above results revealed the potential, reversible male antifertility effect of hydroalcoholic extract F. racemosa bark. | Ahirwar Dheeraj Ahirwar Bharti Kharya MD | 2011 | Journal of Reproduction and Contraception2011，22，1： | 0 |
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