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    题名 作者 年代 出处 被引量
1Synthesis, characterization and theoretical study of 2-azido-4-nitroimidazole-based energetic salts显示文摘The 2-azido-4-nitroimidazole-based energetic salts were synthesized in a simple and straightforward manner. The structures of these new salts were determined by IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. These salts also exhibited high positive enthalpies of formation, high nitrogen content, and moderate detonation properties.Ke-Hui Hou Cong-Ming Ma Zu-Liang Liu 2014Chinese Chemical Letters2014,25,3:2
2Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histone deacetylase inhibitors显示文摘Novel histone deacetylase(HDAC) inhibitors 9a–l were designed and synthesized by coupling the carboxyl group of salicylic acid(SA) with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b–f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat(SAHA), in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in alkylol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat(SAHA), while the tested compounds 9c–f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic agents for the intervention of human cancers.Tao You Ke Chen Fei-Hai Wang Pi-Hong Li Li-Yi Li Zhi-Hao Wu Kong-Hai Ni Zhi-Qiang Zheng 2014Chinese Chemical Letters2014,25,3:2
3Poly(4-vinylpyridine):As a green,efficient and commercial available basic catalyst for the synthesis of chromene derivatives显示文摘Poly(4-vinylpyridine) is reported as a green,commercial available and efficient basic recyclable catalyst for the synthesis of chromene derivatives.This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive runs without any loss of its efficiency.Jalal Albadi Azam Mansournezhad Mohammad Darvishi-Paduk 2013Chinese Chemical Letters2013,24,3:1
4An improved synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane显示文摘An improved and efficient method for synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane(1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl(Cbz) as protection group of amine, the reactions were inmild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%.Dong-Feng Zhang Peng Li Zi-Yun Lin Hai-Hong Huang 2014Chinese Chemical Letters2014,25,3:1
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