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| 1 | Biotechnological approaches in glucosinolate production显示文摘Glucosinolates(GLSs) are sulfur-rich, amino acid-derived defense compounds characteristic of the Brassicales order. In the past, GLSs were mostly known as anti-nutritional factors in fodder, biopesticides in agriculture, and flavors in condiments such as mustard. However, in recent times, GLSs have received increased attention as promoters of human health.This has spurred intensive research towards generating rich sources of health-promoting GLSs. We provide a comprehensive overview of the biotechnologica approaches applied to reach this goal. This includes optimization of GLS production and composition in native, GLS-producing plants, including hairy root and cell cultures thereof, as well as synthetic biology approaches in heterologous hosts, such as tobacco and the microbial organisms Escherichia coli and Saccharomyces cerevisiae. The progress using these different approaches is discussed. | Annette Petersen Cuiwei Wang Christoph Crocoll Barbara Ann Halkier | 2018 | Journal of Integrative Plant Biology2018，60，12： | 6 |
| 2 | Proteomics and Metabolomics of Arabidopsis Responses to Perturbation of Glucosinolate Biosynthesis显示文摘为了理解,种 glucosinolate 新陈代谢的分子的网络,脂肪族的 glucosinolate 生合成的不安在 Arabidopsis 用可诱导的 RNA 干扰(RNAi ) 被建立。二根 RNAi 线为用互补 proteomics 检验全球蛋白质和代谢物变化被选择, metabolomics 来临。包括光合作用和荷尔蒙新陈代谢,蛋白质绑定,精力,应力,和防卫涉及新陈代谢的蛋白质显示出显著回答到 glucosinolate 不安。在平行, metabolomics 在氨基酸,糖类,肽,和荷尔蒙的层次揭示了主要变化。metabolomics 数据与 proteomics 结果被相关并且揭示了在细胞的小径 / 过程和 glucosinolate 新陈代谢之间的亲密分子的连接。这研究提供了 glucosinolate 新陈代谢的分子的网络的一个崭新的看法并且向为提高的防卫和质量设计的基本原理 glucosinolate 打了一个基础。 | Ya-zhou Chen Qiu-Ying Pang Yan He Ning Zhu Isabel Branstrom Xiu-Feng Yan Sixue Chen | 2012 | Molecular Plant2012，5，5： | 3 |
| 3 | Improvement of glucosinolates by metabolic engineering in Brassica crops显示文摘Glucosinolates(GSLs)are a class of sulfur-and nitrogen-containing and amino acid-derived important secondary metabolites,which mainly present in plants of Brassicaceae family,including Brassica crops,such as broccoli,cabbage,and oilseed rape.The bioactive GSL meta bolites confer benefits to plant defense,human health,and the unique flavor of some Brassica crops.However,certain GSL profiles have adverse effects and are known as anti-nutritional factors.This has attracted mounting attempts to increase beneficial GSLs and reduce detrimental ones in the most commonly consumed Brassica crops.We provide a comprehensive overview of metabolic engineering applied in Brassica crops to achieve this purpose,including modulation of GSL biosynthesis,ablation of GSL hydrolysis,inhibition of GSL transport processes,and redirection of meta bolic flux to GSL.Moreover,advances in omics approaches,i.e,genomics,transcriptome,and metabolome,applied in the elucidation of GSL metabolism in Brassica crops,as well as promising and potential genome-editing technologies are also discussed. | Huiying Miao Wei Zeng Jiansheng Wang Fen Zhang Bo Sun Qiaomei Wang | 2021 | aBIOTECH2021，2，3： | 0 |
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