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| 1 | Transcranial magnetic stimulation in animal models of neurodegeneration显示文摘Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research. | Mohammad Uzair Turki Abualait Muhammad Arshad Woo-Kyoung Yoo Ali Mir Reem Fahd Bunyan Shahid Bashir | 2022 | Neural Regeneration Research2022，17，2： | 4 |
| 2 | Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure显示文摘Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy,its underlying mechanism remains unclear.This study investigated the influence of low-frequency repetitive transcranial magnetic simulation on changes in several nonlinear dynamic electroencephalographic parameters in rats with chronic epilepsy and explored the mechanism underlying repetitive transcranial magnetic simulation-induced antiepileptic effects.An epilepsy model was established using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats,which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days.Nonlinear electroencephalographic parameters were obtained from the rats at 7,14,and 28 days post-stimulation.Results showed significantly lower mean correlation-dimension and Kolmogorov-entropy values for stimulated rats than for non-stimulated rats.At 28 days,the complexity and point-wise correlation dimensional values were lower in stimulated rats.Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats,thus explaining its effectiveness in treating epilepsy. | Yinxu Wang Xiaoming Wang Sha Ke Juan Tan Litian Hu Yaodan Zhang Wenjuan Cui | 2013 | Neural Regeneration Research2013，8，27： | 2 |
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