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| 1 | 胰腺星状细胞的功能异质性及其在外泌体领域的新研究进展显示文摘胰腺星状细胞(PSC)是位于胰腺小叶和腺泡周围的一种多能细胞。PSC在正常胰腺中处于静息状态,而在各种病理生理条件的刺激下,PSC会被激活,激活后的PSC可以转化为类似于肌成纤维细胞的激活态表型。与静息态相比,激活态PSC可以增殖并主动迁徙,分泌大量细胞外基质并作为胰腺疾病微环境的重要组分参与调控胰腺癌和慢性胰腺炎的病程进展。同时,大量的研究阐明了PSC具有功能异质性,因其细胞标志物和功能学的差异分为不同的细胞亚群,这些亚群可以单独或协同地调节胰腺癌的发生和发展。PSC的相关外泌体可以通过细胞间的信息传递和物质交换来促进胰腺癌细胞的生长、增殖和侵袭,并以此调控胰腺癌的病情发展。在慢性胰腺炎中,激活态PSC及其衍生的外泌体更是启动和促进胰腺纤维化的重要组分。因此,探讨PSC的功能异质性和其相关的外泌体的研究进展可以为胰腺疾病的治疗提供新的策略和方法。 | 蔡茗 林先盛 邵峰 刘振 孟府陶 黄强 | 2020 | 中国普通外科杂志2020，29，3： | 3 |
| 2 | 胰腺星状细胞与慢性胰腺炎关系的研究进展显示文摘慢性胰腺炎(chronic pancreatitis,CP)是由不同因素造成胰腺组织和功能持续性损害,最终导致胰腺内外分泌功能的永久性丧失,其典型病理表现为胰腺实质纤维化、胰腺细胞萎缩、胰管狭窄或扩张和胰腺微结石。胰腺纤维化是由于过多的细胞外基质(extracellularmatrixc,ECM)在胰腺内沉积所致。 | 李琪毅 姜仕柱 郑仕杰 周颖 | 2012 | 实用医学杂志2012，28，7： | 1 |
| 3 | YAP activates pancreatic stellate cells and enhances pancreatic fibrosis显示文摘Background:Pancreatic stellate cells(PSCs)foster the progression of pancreatic adenocarcinoma and chronic pancreatitis(CP)by producing a dense fibrotic stroma.However,the incomplete knowledge of PSCs biology hampers the exploration of antifibrotic therapies.Here,we explored the role of the Hippo pathway in the context of PSCs activation and experimental CP.Methods:CP model was created in rats with the tail vein injection of dibutyltin dichloride(DBTC).The expression of Yes-associated protein(YAP)in CP tissue was assessed.Primary and immortalized rats PSCs were treated with the YAP-inhibitor verteporfin.Furthermore,YAP siRNA was employed.Subsequently,DNA synthesis,cell survival,levels ofα-smooth muscle actin(α-SMA)protein,presence of lipid droplets and PSCs gene expression were evaluated.Upstream regulators of YAP signaling were studied by reporter gene assays.Results:In DBTC-induced CP,pronounced expression of YAP in areas of tubular structures and periduc-tal fibrosis was observed.Verteporfin diminished DNA replication in PSCs in a dose-dependent fash-ion.Knockdown of YAP reduced cell proliferation.Primary cultures of PSCs were characterized by a de-crease of lipid droplets and increased synthesis ofα-SMA protein.Both processes were not affected by verteporfin.At the non-cytotoxic concentration of 100 nmol/L,verteporfin significantly reduced mRNA levels of transforming growth factor-β1(Tgf-β1)and Ccn family member 1(Ccn1).YAP signaling was acti-vated by TGF-β1,but repressed by interferon-γ.Conclusions:Activated YAP enhanced PSCs proliferation.The antifibrotic potential of Hippo pathway in-hibitors warrants further investigation. | Lennard Spanehl Denis Revskij Karen Bannert Luise Ehlers Robert Jaster | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，6： | 0 |
| 4 | 胰腺星状细胞与胰腺癌前病变的关系及干预设想显示文摘胰腺星状细胞(PSC)激活在正常胰腺-胰腺炎症-胰腺癌前病变-胰腺癌的进展过程中发挥重要作用,这是由PSC的生物学特性和功能异质性决定的。PSC通过分泌、自噬、能量代谢和微环境失衡等机制影响胰腺炎症和胰腺癌前病变,而抑制PSC激活、促进活化PSC状态改变及诱导PSC凋亡等可能是阻止胰腺炎症向胰腺癌前病变演化和进展的重要干预措施。 | 夏时海 | 2022 | 中华胰腺病杂志2022，22，2： | 0 |
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