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| 1 | 五倍子化学成分和药理作用的研究进展显示文摘五倍子Galla chinensis为一味收涩性的中药材,有敛肺降火、涩肠止泻、敛汗、止血、收湿敛疮的功效。五倍子化学成分多样,至今已被鉴定的化学成分主要包括鞣质、酚酸、氨基酸、脂肪酸、鞣花酸及其他成分等。现代研究表明,五倍子具有抗龋齿、抗菌、止泻、止血、抗炎、促进伤口愈合、抗癌、清除自由基、抗氧化等多种药理作用。对五倍子化学成分和药理作用的研究进展进行综述,以更好地了解五倍子的特征,扩大其应用范围,为其临床应用提供科学依据。 | 梁正 徐强 张倩 刘天凤 张朝晖 | 2022 | 中草药2022，53，18： | 25 |
| 2 | Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro显示文摘To determine the chemical composition of Galla chinensis extract(GCE) by several analysis techniques and to compare the efficacy of GCE and its main component(s) in inhibition of enamel demineralization,for the development of future anticaries agents,main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry(LC-TOF-MS) and quantified by high-performance liquid chromatography-diode array detector(HPLC-DAD).Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography.Then,bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times.Each cycle included 5-min applications with one of four treatments:4 g?L 21 GCE solution,4 g?L 21 gallic acid(GA) solution,1 g?L 21 NaF solution(positive control),deionized water(DDW,negative control),and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer.Acidic buffers were retained for calcium analysis.The main organic composition of GCE were GA and its isomer,and,to a lesser extent,small molecule gallotannins.The content of GA in GCE was 71.3%60.2%(w/w).Inorganic ions were present in various amounts,of which Ca was(13662.82) mg?g 21,and Zn was(6.860.1) mg?g 21.No F was detected in GCE.In pH cycling,GA showed an effect similar to GCE in inhibiting enamel demineralization(P.0.05).GA was found to be the main effective,demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents. | Xue-Lian Huang Ming-Dong Liu Ji-Yao Li Xue-Dong Zhou Jacob M ten Cate | 2012 | International Journal of Oral Science2012，4，3： | 11 |
| 3 | 中药五倍子提取物对牙本质表面性能的强化作用显示文摘目的:评价中药五倍子对牙本质抗酸作用及表面强化的影响。方法:45个牛牙本质标本随机分为3组,以4 g/L五倍子提取液为实验药物,1 g/L NaF为阳性对照组,去离子水为阴性对照组,同时进行体外pH循环致龋实验。采用显微硬度仪测定各样本pH循环前后表面显微硬度,观察牙本质显微硬度的变化,并用扫描电镜和X线能谱仪分析pH循环后各组牙本质表面形貌和元素含量。数据采用SPSS17.0软件包进行统计学分析。结果:与去离子水相比,4 g/L五倍子可以显著减少牙本质表面显微硬度的降低(P<0.05),效果与1 g/L NaF无显著差异(P>0.05)。五倍子组和NaF组牙本质小管大部分呈闭合和堵塞状,而去离子水组牙本质小管呈开放状。五倍子组和NaF组的Ca和P成分显著高于去离子水组(P<0.05)。结论:五倍子可增强牙本质表面的抗酸能力,强化牙本质的表面性能,有抑制牙本质龋进展、保护牙本质免受酸腐蚀的作用。 | 邓盟 黎红 董孝立 施桔红 | 2013 | 上海口腔医学2013，22，2： | 7 |
| 4 | 酪蛋白磷酸钙复合体对乳牙脱矿釉质再矿化作用的体外实验研究显示文摘目的:用Micro-CT定量研究酪蛋白磷酸钙复合体(CPP-ACP)对乳牙脱釉质的再矿化效能。方法:纳入6~8岁因乳牙滞留拔除的乳下颌中切牙20颗,颊面留出约2 mm×2 mm开窗区,其余部分用抗酸性指甲油封闭。人工釉质脱矿后随机分为A组(去离子水)、B组(0.2%NaF)、C组(10%CPP-ACP)、D组(10%CPP-ACP+0.2%NaF)(n=5)。应用Micro-CT和三维重建技术,观察各组再矿化后2及4周的脱矿区体积变化。结果:人工脱矿后各组内试件的脱矿区体积无明显差别(P>0.05);再矿化处理后第2周和4周,B、C、D组试件的脱矿区体积明显小于A组(P<0.05),且D组脱矿区体积显著小于B、C组(P<0. 05)。结论:CPP-ACP对乳牙早期釉质龋有再矿化作用,低浓度氟化物联合使用时再矿化效果更好。 | 赵岩 高平 | 2019 | 实用口腔医学杂志2019，35，5： | 4 |
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