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| 1 | Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury显示文摘Netrin-1 is currently one of the most highly studied axon guidance factors. Netrin-1 is widely expressed in the embryonic central nervous system, and together with the deleted in colorectal cancer and uncoordinated locomotion-5 homolog B receptors, netrin-1 plays a guiding role in the construction of neural conduction pathways and the directional migration of neuronal cells. In this study, we established a rat middle cerebral artery ischemia reperfusion model using the intraluminal thread technique. Immunofluorescence microscopy showed that the expression of netrin-1 and deleted in colorectal cancer in the ischemic penumbra was upregulated at 1 day after reperfusion, reached a peak at 14 days, and decreased at 21 days. There was no obvious change in the expression of uncoordinated locomotion-5 homolog B during this time period. Double immunofluorescence labeling revealed that netrin-1 was expressed in neuronal cells and around small vessels, but not in astrocytes and microglia, while deleted in colorectal cancer was localized in the cell membranes and protrusions of neurons and astrocytes. Our experimental findings indicate that netrin-1 may be involved in post-ischemic repair and neuronal protection via deleted in colorectal cancer receptors. | Xiaodan Wang Jinming Xu Jieqin Gong Hui Shen Xiaoping Wang | 2013 | Neural Regeneration Research2013，8，1： | 1 |
| 2 | Profile of Prof. Weizhi Ji显示文摘Prof.Weizhi Ji is a distinguished scientist in nonhuman primate reproduction and developmental biology.He is devoted to uncovering the regulation mechanisms of early embryo development and stem cell pluripotency,and to understanding the pathogenesis of human diseases using nonhuman primate (NHP)models.Through decades of research, Prof.Ji has developed a series of research systems and technologies in NHPs including in vitro fertilization,early embryo culture,gene editing and stem cell isolation and culture.Using these systems,he has made remarkable original and fundamental achievements in the molecular mechanisms of NHP reproduction and development,stem cell self-renewal and differentiation.His research first demonstrates the developmental pluripotency of monkey pluripotent stem c.ells (PSCs)and paves the way of using gene editing technology to establish primate models. | | 2019 | Science China(Life Sciences)2019，62，1： | 0 |
| 3 | 雪旺细胞联合高压氧治疗对脑缺血代偿区netrin-1表达的影响显示文摘目的研究高压氧治疗与雪旺细胞联合移植对脑缺血代偿区netrin-1的表达的影响。方法建立大鼠大脑中动脉闭塞模型,分为第1组雪旺细胞移植和第2组雪旺细胞移植联合高压氧治疗。用RT-PCR观察netrin-1 mRNA表达变化情况。结果联合治疗组netrin-1 mRNA比单纯细胞移植组降低1/4。结论 netrin-1在高压氧的作用下降低,可能的原因为高压氧增加自由基的生成,自由基导致netrin-1的降低。 | 刘艳丽 李婷婷 张华 | 2013 | 国际检验医学杂志2013，34，8： | 0 |
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