共被期刊论文引用了5次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | VEGF分泌量及分泌来源对肿瘤血管生长影响的数值模拟显示文摘目的数值模拟研究血管内皮生长因子(vascular endothelial growth factor,VEGF)分泌量及分泌来源对肿瘤血管生成的影响。方法建立肿瘤内外血管生成的二维离散数学模型。围绕VEGF的分泌及其诱导新生血管形成肿瘤富血管区的过程,考虑细胞外基质的旁分泌作用以及对内皮细胞运动的趋触作用,以微血管密度作为定量指标,探讨VEGF的分泌量及不同的分泌来源对血管生成的影响。结果肿瘤增殖细胞区、VEGF高浓度区、富血管区三者统一,微血管密度与VEGF的表达有关,随着增殖细胞区域的扩大,即VEGF的表达越来越多,微血管密度也越来越大,但在不同类型的肿瘤中,VEGF不同分泌来源的比重与微血管密度无明显相关性。结论模型探讨了VEGF分泌量及分泌来源对肿瘤血管生成的影响,其中对VEGF的不同分泌来源的考虑可作为研究靶向VEGF治疗肿瘤的模型基础。 | 时玉娟 蔡彦 陈强 李志勇 | 2013 | 医用生物力学2013，28，6： | 7 |
| 2 | 抗血管生成治疗抑制实体肿瘤细胞生长的数值模拟:应用血管生成与肿瘤生长的耦合数学模型显示文摘为研究抗血管生成因子angiostatin和抗血管生成药物endostatin对肿瘤血管生成和肿瘤细胞的抑制作用,建立耦合肿瘤血管生长、肿瘤生长和血液灌注的数学模型.模拟结果显示抗血管生成因子angiostatin和抗血管生成药物endostatin可明显抑制血管生成和减少肿瘤细胞数量,从而起到改善肿瘤组织内部异常微环境的作用.模型可作为肿瘤抗血管生成治疗的一种理论研究. | 蔡彦 吴洁 许世雄 龙泉 姚伟 | 2011 | 应用数学和力学2011，32，10： | 4 |
| 3 | Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth显示文摘To investigate the inhibiting effects of the anti-angiogenic factor andostatin and the anti-angiogenic drug endostatin on tumour angiogenesis and tumour cells, a coupled mathematical model of tumor angiogenesis with tumour growth and blood perfusion is developed. Simulation results show that angiostatin and endostatin can improve the abnormal microenvironment inside the tumour tissue by effectively inhibiting the process of tumor angiogenesis and decreasing tumour cells. The present model can be used as a valid theoretical method in the investigation of the tumour anti-angiogenic therapy. | 蔡彦 吴洁 许世雄 龙泉 姚伟 | 2011 | Applied Mathematics and Mechanics(English Edition)2011，32，10： | 1 |
| 4 | HER-2影响实体肿瘤血管生成的数值模拟研究显示文摘目的数值模拟人类表皮生长因子受体2(HER-2)影响下的肿瘤血管生成,并探究不同用药方案对抗血管生成的影响。方法依据理论、实验建立包含HER-2影响项的偏微分方程组,运用欧拉-拉格朗日混合方法进行数值离散与模拟,通过比较模拟数据、图像分析结果。结果数值模拟结果显示HER-2促进了实体肿瘤血管的生长;靶向HER-2的药物治疗方法可以抑制肿瘤血管的生长,用药要尽可能早,并且在一定范围内增加药量可以加强抑制作用。结论建立的模型可以有效模拟HER-2对肿瘤血管生长的影响以及不同用药方案对治疗效果的影响。该法为药物和临床研究提供参考与平台。 | 苏灵暄 曹艳君 姚伟 许世雄 | 2013 | 生物医学工程学进展2013，34，4： | 1 |
| 5 | Lyapunov stability of competitive cells dynamics in tumor mechanobiology显示文摘Poromechanics plays a key role in modelling hard and soft tissue behaviours,by providing a thermodynamic framework in which chemo-mechanical mutual interactions among fluid and solid constituents can be consistently rooted,at different scale levels.In this context,how different biological species(including cells,extra-cellular components and chemical metabolites)interplay within complex environments is studied for characterizing the mechanobiology of tumor growth,governed by intra-tumoral residual stresses that initiate mechanotransductive processes deregulating normal tissue homeostasis and leading to tissue remodelling.Despite the coupling between tumor poroelasticity and interspecific competitive dynamics has recently highlighted how microscopic cells and environment interactions influence growth-associated stresses and tumor pathophysiology,the nonlinear interlacing among biochemical factors and mechanics somehow hindered the possibility of gaining qualitative insights into cells dynamics.Motivated by this,in the present work we recover the linear poroelasticity in order to benefit of a reduced complexity,so first deriving the well-known Lyapunov stability criterion from the thermodynamic dissipation principle and then analysing the stability of the mechanical competition among cells fighting for common space and resources during cancer growth and invasion.At the end,the linear poroelastic model enriched by interspecific dynamics is also exploited to show how growth anisotropy can alter the stress field in spherical tumor masses,by thus indirectly affecting cell mechano-sensing. | Angelo Rosario Carotenuto Arsenio Cutolo Stefania Palumbo Massimiliano Fraldi | 2021 | Acta Mechanica Sinica2021，37，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员