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| 1 | 肥大细胞对针灸治疗过程中的物理刺激的敏感性机制研究显示文摘研究人肥大细胞膜上可能参与针灸效应的机械和温度敏感性离子通道蛋白的力和温度的响应特征.采用膜蛋白免疫印迹、电生理膜片钳技术、流动腔技术、胞内钙荧光成像和荧光分光光度等方法,观察相关通道特异性阻断剂对机械和温度刺激激活电流、胞内钙浓度、组胺分泌释放率的影响.实验证实,人肥大细胞膜上存在香草素瞬时受体电位通道2(TRPV2)蛋白的表达,该通道为肥大细胞在受外界机械和温度刺激时的直接激活提供了有效的信号传递通路,而胞内游离钙浓度的增加是促使其产生组胺分泌释放的重要环节之一.肥大细胞生物反应信号的启动和途径为针灸信号传导机制的研究提供了可靠的科学依据. | 朱海宁 张迪 黄猛 杨玉华 萨喆燕 丁光宏 | 2013 | 复旦学报(自然科学版)2013，52，5： | 18 |
| 2 | Mechanisms of Qi-blood circulation and Qi deficiency syndrome in view of blood and interstitial fluid circulation显示文摘OBJECTIVE: Based on comparison between fundamental theories of Traditional Chinese Medicine (TCM) and Western Medicine (WM) and modern scientific research on meridians, we find that 'Qi' in TCM is closely related to tissue fluid. In this study, the essence of Qi is explored in the view of circulation of blood and interstitial fluid. METHODS: Because the concept of Qi is complicated, Qi deficiency syndrome (QDS) is chosen to probe the relationship between of Qi deficiency and Qi-blood circulation (QBC). We analyze Qi-blood theory in terms of WM, set up a hemodynamic model to describe QBC, and review clinical research on QDS in the view of blood-interstitial fluid circulation. RESULTS: QDS is caused by imbalances of substance exchanges between blood and interstitial fluid, leading to an increase in the interstitial liquid volume or a decrease in nutrients and retention ofmetabolic wastes in interstitial fluid. CONCLUSION: This study describes the essence of Qi, providing support for further research on theories of Qiand Qi-blood circulation inTCM. | Wei Yao Hongwei Yang Guanghong Ding | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 8 |
| 3 | Analytic solutions of the interstitial fluid flow models显示文摘In this paper,we present the analytic solutions of several continuum porous media models that describe the interstitial fluid flow in the interosseous membrane.We first compare the results of the Brinkman,Stokes and Darcy systems in describing the isotropic interstitial fluid flows.Our calculations show that the Stokes equations can well approximate the Brinkman equations when the Darcy number Da 0.2,while the Darcy model is an appropriate approximation to the Brinkman model in the interosseous membrane when4Da2 10.Yet,in most cases,the anisotropy dominates the interstitial fluid.Therefore,we build an anisotropic Darcy model and show that an isotropic model can be used as a suitable approximation when the ratio between the transverse and longitudinal permeabilities is no larger than 20.Lastly,we take the blood flow in capillaries into consideration as well and introduce the coupled Stokes-Darcy system to describe the cases comprising both the capillary and the interstitial domain.Our results reveal that the profile of the interface exchange flow is not exactly in the linear form as was widely adopted in the numerical simulation,instead,the flux near the artery and the vein is more significant,which in turn results in the increase of the maximum horizontal velocity in the interstitial space while the outflow rate remains the same. | 姚伟 李亚贝 陈南 | 2013 | Journal of Hydrodynamics2013，25，5： | 2 |
| 4 | 两穴位心电统计学特异性的发现和穴位点定位显示文摘在孔最穴和尺泽穴上设计了一个心电信号采集实验,发现了两穴位在心电信号上具有统计学特异性:两穴位上采集的心电信号的二阶统计量与其四周4个非穴位点处采集的心电信号的二阶统计量具有明显区别,且穴位点处心电信号的二阶统计量要明显高于紧挨其周围的4个非穴位点,并用小样本t检验,对所得结论的可信度进行了评价,结果表明:该结论确实具有较高的可信度.这一特性的发现为穴位点定位提供了一个可供选择的方法. | 诸葛俊贵 谭永红 | 2012 | 上海师范大学学报(自然科学版)2012，41，3： | 1 |
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