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1Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil 2016World Journal of Gastroenterology2016,22,45:3
2羟基柠檬酸研究进展显示文摘羟基柠檬酸主要存在于藤黄属植物内,作为减肥型膳食补充剂的有效成分,具有减肥、增强有氧运动耐力、除结石、降血脂和改善心脑血管的作用。本文主要从制备、检测、生物活性、膳食风险四个方面对羟基柠檬酸进行综述,并展望其未来发展趋势和产品开发所面临的挑战。俞泉 胡一鸿 2020生命的化学2020,40,3:3
3No evidence demonstrating hepatotoxicity associated with hydroxycitric acid显示文摘Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingredients, some do not contain HCA. Case studies reported to date have not considered in depth the literature on the numerous animal and human studies that have been conducted on the safety and effi cacy of HCA. No HCA-associated hepatotoxicity or treatment-related adverse effects have been reported in these studies, and thus it is premature to make the assumptions presented in the recent case studies regarding Hydroxycut. If it is established in well controlled studies that the use of these formulations with and/or without HCA can result in the occurrence or progression of hepatotoxicity, additional studies should be conducted to characterize the causative factor(s).Sidney J Stohs Harry G Preuss Sunny E Ohia Gilbert R Kaats Carl L Keen Lonnie D Williams George A Burdock 2009World Journal of Gastroenterology2009,15,32:1
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