| 1 | New technologies in gastrointestinal research显示文摘This issue presents different new techniques aiming to increase our understanding of the gastrointestinal system and to improve treatment. The technologies cover selected methods to evoke and assess gut pain, new methods for imaging and physiological measurements, histochemistry, pharmacological modelling etc. There is no doubt that the methods will revolutionize the diagnostic approach in near future. | Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 1 |
| 2 | Single-cell profiling of the pig cecum at various developmental stages显示文摘The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial defense.Single-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and disease.Although such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains unexplored.Here,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in humans.An increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental stages.Moreover,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell types.Cell-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other stages.NKT cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 pairs.This study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages. | Yan-Yuan Xiao Qing Zhang Fei Huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei Xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen Yang Bin Yang Lu-Sheng Huang | 2024 | Zoological Research2024，45，1： | 0 |
| 3 | 基于五元件模型的小肠动态粘弹特性研究显示文摘进行了小肠动态粘弹特性的研究,应用五元件模型描述了小肠材料的松弛过程,得到了小肠材料的粘弹性本构方程。搭建了物理仿真平台,设计了负压吸附夹具,进行了小肠剪切松弛实验,实验验证了模型的有效性并进行了模型参数辨识。将该模型应用于振动式胶囊机器人,根据机器人的运动参数研究了小肠在一定频率下的动态粘弹性,得到了以下结论:五元件模型可以很好地拟合小肠材料松弛过程;小肠材料本构方程参数不是固定的而是随应变变化的;在胶囊自由振动过程中,整个系统呈现过阻尼状态,即非往复的衰减运动。 | 张诚 刘浩 苏刚 谭人嘉 李洪谊 | 2012 | 高技术通讯2012，22，9： | 0 |
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