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| 1 | 术后腹膜粘连的发生机制及其防治显示文摘术后腹膜粘连是腹部手术的常见并发症,其发生率可达90%以上。在发生粘连的病例中,超过80%的患者在切口与大网膜之间形成粘连,50%的病例涉及小肠[1]。引起腹膜粘连的原因主要有创伤、缺血、感染、异物;其后果主要包括肠梗阻、再次手术困难、慢性腹痛及女性不孕等。我们仅就术后腹膜粘连的发生发展机制及其防治进行综述。 | 白景瑞 吴咸中 | 2011 | 中国中西医结合外科杂志2011，17，3： | 20 |
| 2 | 贝伐珠单抗联合化疗治疗晚期卵巢癌所致粘连性肠梗阻的疗效观察显示文摘目的:观察腹腔灌注贝伐珠单抗联合化疗治疗卵巢癌所致粘连性肠梗阻的临床疗效,分析腹腔内血管内皮生长因子(VEGF)水平对贝伐珠单抗治疗卵巢癌腹腔粘连的临床意义。方法:将62例卵巢癌伴恶性不完全性肠梗阻患者随机分为实验组(n=32)和对照组(n=30),均用奥曲肽(60 mg/d连续3天)全身治疗,3周重复1次;同时腹腔内给予灌注化疗,每3周重复1次,连续治疗2周期。对照组给予吉西他滨和卡铂腹腔灌注治疗,实验组在上述治疗基础上联合贝伐珠单抗(5 mg/kg)治疗。评价患者疗效、不良反应。酶联免疫吸附法(ELISA)检测62例患者治疗前、后腹腔中VEGF水平。结果:实验组的有效率为87.50%,对照组为43.33%,差异有统计学意义(P<0.05)。实验组和对照组患者耐受良好,不良反应无明显差异。治疗后对照组腹水VEGF水平为(139.89±10.89)pg/mL,明显低于治疗前的(310.59±13.63)pg/mL(P<0.05);实验组治疗后腹水VEGF水平为(81.57±4.71)pg/mL,明显低于治疗前的(309.67±11.02)pg/mL(P<0.05)。治疗后VEGF水平实验组较对照组下降更为显著(P<0.05)。结论:贝伐珠单抗联合化疗治疗晚期卵巢癌粘连性肠梗阻优于单纯腹腔灌注化疗,不良反应较少,安全性耐受性好。 | 付艳 孙志佳 李东惠 胡佳 李晨曦 赵晖 杜楠 | 2021 | 现代肿瘤医学2021，29，15： | 10 |
| 3 | 羧甲基壳聚糖防粘连粉雾剂的应用及作用机制的研究显示文摘目的:探讨羧甲基壳聚糖防粘连粉雾剂在大鼠腹腔内粘连模型中的应用及其可能的作用机制。方法:将60只SD大鼠随机分成3组,即假手术组(n=20)、对照组(肠粘连模型组,n=20)和实验组(羧甲基壳聚糖组,n=20)。比较3组大鼠在术后第7天、第14天时腹腔粘连发生率和程度的影响,并用光学显微镜对大鼠腹腔内粘连标本及腹膜反应程度进行病理观察。结果:对照组各时间段发生腹腔内粘连的概率和粘连程度最高,实验组次之,假手术组最轻。结论:羧甲基壳聚糖防粘连粉雾剂能明显减少大鼠术后腹腔内粘连的发生。 | 洪欣 沈柏用 韩宝三 | 2009 | 外科理论与实践2009，14，4： | 3 |
| 4 | 上腹部手术史患者直视微创与开腹胆囊切除术的疗效观察显示文摘目的探讨有上腹部手术史的患者行直视微创胆囊切除术与传统开腹胆囊切除术对比研究。方法将有上腹部手术史的39例患者分为2组,行直视微创胆囊切除术者23例为观察组,传统开腹胆囊切除术16例为对照组,分析观察2种手术方法的临床疗效。结果 2组术中出血量、进食时间差异无统计学意义(P>0.05)。观察组切口感染率、下床活动时间、住院时间均优于对照组,差异有统计学意义(P<0.05)。对照组手术时间优于观察组,差异有统计学意义(P<0.05)。结论对有上腹部手术史的患者行直视微创胆囊切除术安全、有效。 | 张志英 马顺茂 孟繁杰 王海刚 尹东剑 | 2010 | 河北医科大学学报2010，31，7： | 0 |
| 5 | 术后腹盆腔黏连与细胞因子关联的研究进展显示文摘目的介绍术后黏连与细胞因子关联的研究进展。方法查阅近几年国内外文献资料并进行总结和归纳。结果细胞因子在术后黏连形成中起重要作用。结论特异性抗细胞因子药物有望成为治疗术后黏连的新方法。 | 蔡鸿福 侯连兵 | 2010 | 中国现代应用药学2010，27，10： | 0 |
| 6 | Decreasing recurrent bowel obstructions,improving quality of life with physiotherapy:Controlled study显示文摘AIM To compare(1) quality of life and(2) rate of recurrent small bowel obstructions(SBO) for patients treated with novel manual physiotherapy vs no treatment. METHODS One hundred and three subjects(age 19-89) with a history of recurrent adhesive SBO were treated with a manual physiotherapy called the Clear Passage Approach(CPA) which focused on decreasing adhesive crosslinking in abdominopelvic viscera. Pre-and post-therapy data measured recurring obstructions and quality of life, using a validated test sent 90 d after therapy. Results were compared to 136 untreated control subjects who underwent the same measurements for subjects who did not receive any therapy, which is the normal course for patients with recurring SBO. Comparison of the groups allowed us to assess changes when the physiotherapy was added as an adjunct treatment for patients with recurring SBO.RESULTS Despite histories of more prior hospitalizations, obstructions, surgeries, and years impacted by bowel issues, the 103 CPA-treated subjects reported a significantly lower rate of repeat SBO than 136 untreated controls(total obstructions P = 0.0003; partial obstructions P = 0.0076). Subjects treated with the therapy demonstrated significant improvements in five of six total domains in the validated Small Bowel Obstruction Questionnaire(SBO-Q). Domains of diet, pain, gastrointestinal symptoms, quality of life(QOL) and pain severity when compared to post CPA treatment were significantly improved(P < 0.0001). The medication domain was not changed in the CPA treated group(P = 0.176).CONCLUSION CPA physical therapy was effective for patients with adhesive SBO with significantly lower recurrence rate, improvement in reported symptoms and overall quality of life of subjects. | Amanda D Rice Kimberley Patterson Evette D Reed Belinda F Wurn Kristen Robles Bernhard Klingenberg Leonard B Weinstock Janey SA Pratt C Richard King III Lawrence J Wurn | 2018 | World Journal of Gastroenterology2018，24，19： | 0 |
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