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| 1 | Characteristics and long-term prognosis of patients with rectal neuroendocrine tumors显示文摘AIM:To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors.METHODS:The records of 48 patients with rectal neuroendocrine tumors who were treated at the Cancer Institute and Hospital,Chinese Academy of Medical Sciences,Beijing,from March 2004 to September 2009were retrospectively reviewed.The clinicopathological data were extracted and analyzed,and patients were followed-up by telephone or follow-up letter to determine their survival status.Follow-up data were available for all 48 patients.Uni-and multivariate Cox regression analyses were performed to determine the prognostic factors significantly associated with overall survival.RESULTS:The tumors occurred mostly in the middle and lower rectum,and the most prominent symptoms experienced by patients were hematochezia and diarrhea.The median distance between the tumors andthe anal edges was 5.0±2.257 cm,and the median diameter of the tumors was 0.8±1.413 cm.The major pathological type was a typical carcinoid tumor,which accounted for 93.8%(45/48)of patients.Tumor-nodemetastasis(TNM)stagesⅠ,Ⅱ,ⅢandⅣtumors accounted for 78.8%,3.9%,9.6%and 7.7%of patients,respectively.The main treatment method,in 72.9%(35/48)of patients,was transanal extended excision.The 1-,3-and 5-year survival rates of the whole group of patients were 100%,93.7%,and 91.3%,respectively.Univariate analysis showed that age(P=0.032),tumor diameter(P<0.001),histological type(P<0.001),TNM stage(P<0.001),and surgical approach(P=0.002)were all prognostic factors.On multivariate analysis,only the pathological type was shown to be an independent prognostic factor(HR=2.797,95%CI:1.676-4.668,P=0.004).CONCLUSION:In patients with rectal neuroendocrine tumors,TNM stage Ⅰ is the most common stage found,and lymph node or distant metastases are rarely seen.The pathological type of the tumor is an independent prognostic factor. | Yihebali Chi Feng Du Hong Zhao Jin-Wan Wang Jian-Qiang Cai | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 2 | Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin. | Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba | 2009 | World Journal of Gastroenterology2009，15，17： | 4 |
| 3 | 高频超声小探头辅助内镜下粘膜切除术治疗微小直肠类癌的回顾性分析显示文摘目的归纳直肠类癌内镜超声图像特征与染色放大内镜腺管开口形态特点,探讨高频超声小探头辅助内镜下粘膜切除术(endoscopic mucosal resection,EMR)治疗微小直肠类癌的安全性、可行性。方法37例直肠隆起性病变,予内镜下观察病灶腺管开口,小探头高频超声探测病灶来源、大小、性质及浸润性;其中29例行EMR。结果共8例经病理检查确诊为直肠类癌,平均病变直径(6.25±2.46)mm,内镜下扁平或轻度隆起,呈黄白色,表面粘膜正常,腺管开口Ⅰ型,超声内镜下表现为低回声团影,多局限于粘膜下层,不侵犯固有肌层,未探及直肠周围淋巴结,病理均显示残端肿瘤完全切除。操作过程顺利,无穿孔和大出血等严重并发症出现,随访6-54月,未见一例复发、转移,但1例死于结肠癌。结论高频超声小探头检查可初步明确病变来源及层次,可安全有效地指导直肠微小类癌EMR的治疗。 | 余细球 刘锦涛 侯华军 陈彩霞 欧阳爱云 | 2010 | 中国现代手术学杂志2010，14，1： | 4 |
| 4 | 直肠神经内分泌肿瘤的内镜诊治进展显示文摘直肠是胃肠胰神经内分泌肿瘤(neuroendocrine tumors,NETs)最常见的发生部位之一.近年来随着结肠镜筛查的普及,直肠NETs的检出率较以前显著升高,且绝大部分是无周围侵犯和远处转移的局限期病变.因此内镜下治疗成为直肠NETs的主要治疗手段.目前主要应用的内镜治疗方法包括内镜下黏膜切除术、内镜下黏膜剥离术和经肛内镜微创手术等.临床应用中上述方法不断被改进,互有优势,互相补充,极大地提高了直肠NETs的完整切除率和远期疗效. | 张昱 郭强 | 2018 | 世界华人消化杂志2018，26，16： | 2 |
| 5 | 三维超声内镜的概况及临床应用显示文摘三维超声内镜(3D-EUS)是建立在二维超声内镜基础上的超声影像技术,是计算机软件技术进一步发展的产物。其不仅能够提供病灶的立体结构,还可显示冠状、矢状及横断面的扫描图像,并可进一步测定病灶的体积,从而提高了诊断准确率,在胃肠道疾病的临床诊断方面有较高的价值。 | 赵韫嘉 戈之铮 | 2008 | 胃肠病学和肝病学杂志2008，17，8： | 1 |
| 6 | 超声内镜在直肠类癌诊治中的应用显示文摘类癌又称嗜银细胞癌,是一种临床上少见的神经内分泌肿瘤,多发于胃肠道部位。直肠类癌由于生长缓慢,早期患者多无症状,大多数是因其他肠道疾病行肠镜检查时发现,少数可能有肛周不适、便秘、大便形状改变等表现,易误诊、漏诊,延误治疗。目前,随着内镜及超声影像技术的不断发展,直肠类癌的检出率不断提高,治疗也更微创、简单。近年来,我院采用超声内镜对直肠类癌患者进行诊治,效果较好,现报道如下。 | 童秀萍 洪小飞 吴深宝 朱旭星 何建 华 | 2013 | 浙江医学2013，，4： | 0 |
| 7 | 改制针状刀在消化道黏膜病变切除术中出血的止血应用显示文摘目的评价改制针状刀在消化道黏膜病变切除术中出血的止血效果。方法对内镜下黏膜病变切除术时36例出血的患者均用改制针状刀单极电凝止血,观察效果。结果圈套器电切术引起出血16例患者,12例用改制针状刀成功止血;内镜下黏膜切除术引起出血13例患者,11例用改制针状刀成功止血;黏膜下层剥离术引起出血7例患者,6例用改制针状刀在镜下成功止血。结论在消化道黏膜病变切除术中出血,改制针状刀有良好的止血效果。 | 魏义胜 秦光明 何玉柱 孔小静 郭玲 | 2011 | 中国医师进修杂志2011，34，25： | 0 |
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