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| 1 | Non-invasive assessment of liver fibrosis in chronic liver diseases:Implementation in clinical practice and decisional algorithms显示文摘Chronic hepatitis B and C together with alcoholic and non-alcoholic fatty liver diseases represent the major causes of progressive liver disease that can eventually evolve into cirrhosis and its end-stage complications,including decompensation,bleeding and liver cancer.Formation and accumulation of fibrosis in the liver is the common pathway that leads to an evolutive liver disease.Precise definition of liver fibrosis stage is essential for management of the patient in clinical practice since the presence of bridging fibrosis represents a strong indication for antiviral therapy for chronic viral hepatitis,while cirrhosis requires a specif ic follow-up including screening for esophageal varices and hepatocellular carcinoma.Liver biopsy has always represented the standard of reference for assessment of hepatic fibrosis but it has some limitations being invasive,costly and prone to sampling errors.Recently,blood markers and instrumental methods have been proposed for the non-invasive assessment of liver fibrosis.However,there are still some doubts as to their implementation in clinical practice and a real consensus on how and when to use them is not still available.This is due to an unsatisfactory accuracy for some of them,and to an incomplete validation for others.Some studies suggest that performance of non-invasive methods for liver fibrosis assessment may increase when they are combined.Combination algorithms of non-invasive methods for assessing liver fibrosis may represent a rational and reliable approach to implement non-invasive assessment of liver fibrosis in clinical practice and to reduce rather than abolish liver biopsies. | Giada Sebastiani | 2009 | World Journal of Gastroenterology2009，15，18： | 12 |
| 2 | 维吾尔族和汉族子宫颈鳞癌中galectin-1、LN及VEGF的表达和意义显示文摘目的检测维吾尔族(维族)和汉族宫颈癌发生、发展过程中半乳糖凝集素1(galectin-1)、层粘连蛋白(LN)及血管内皮生长因子(VEGF)的表达及相关性。方法采用免疫组织化学PV9000二步法检测galectin-1、LN及VEGF蛋白在慢性宫颈炎(维族30例,汉族30例)、宫颈鳞癌(维族45例,汉族35例)中的表达。结果 galectin-1、VEGF在维族和汉族宫颈鳞癌组织中的表达明显高于慢性宫颈炎组织(P<0.05),LN在维族和汉族宫颈鳞癌组织中的表达明显低于慢性宫颈炎组织(P<0.05);并且galectin-1与VEGF呈正相关(r=1.000,P<0.01),LN分别与galectin-1、VEGF呈负相关(r=-1.000,P<0.01)。结论 galectin-1、LN和VEGF蛋白在宫颈鳞癌发生、发展中可能起相互作用;维族和汉族患者虽然有不同的基因背景差异,但galectin-1、LN和VEGF蛋白表达无明显差异。 | 杨波 刘迎嘉 张晨 | 2014 | 重庆医学2014，43，10： | 1 |
| 3 | 层粘连蛋白-111在血管生成中作用的研究进展显示文摘层粘连蛋白是细胞外基质中的一种非胶原性糖蛋白,至今已发现有15种亚型。但是各亚型间功能有所差别,主要在体内参与细胞黏附、转移、分化、生长,以及信号转导、组织修复。而且层粘连蛋白在血管生成中也具有重要作用。本文旨在对层粘连蛋白亚型-111在血管生成中的作用及研究现状作一综述。 | 李锦锦 吴军卫 柴新群 | 2012 | 国际外科学杂志2012，39，9： | 1 |
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