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| 1 | Impact of hepatitis B virus infection on hepatic metabolic signaling pathway显示文摘A growing body of epidemiologic research has demonstrated that metabolic derangement exists in patients with hepatitis B virus(HBV) infection, indicating that there are clinical associations between HBV infection and host metabolism. In order to understand the complex interplay between HBV and hepatic metabolism in greater depth, we systematically reviewed these alterations in different metabolic signaling pathways due to HBV infection. HBV infection interfered with most aspects of hepatic metabolic responses, including glucose, lipid, nucleic acid, bile acid and vitamin metabolism. Glucose and lipid metabolism is a particular focus due to the significant promotion of gluconeogenesis, glucose aerobic oxidation, the pentose phosphate pathway, fatty acid synthesis or oxidation, phospholipid and cholesterol biosynthesis affected by HBV. These altered metabolic pathways are involved in the pathological process of not only hepatitis B, but also metabolic disorders, increasing the occurrence of complications, such as hepatocellular carcinoma and liver steatosis. Thus, a clearer understanding of the hepatic metabolic pathways affected by HBV and its pathogenesis is necessary to develop more novel therapeutic strategies targeting viral eradication. | Yi-Xian Shi Chen-Jie Huang Zheng-Gang Yang | 2016 | World Journal of Gastroenterology2016，22，36： | 9 |
| 2 | 肝X受体:代谢疾病药物研发的新方向显示文摘在哺乳动物中,肝X受体(LXR)是调节脂质平衡的关键物质。这类转录因子通过组织依赖的方式控制着一系列基因的表达,而这些基因能够调节胆固醇的吸收、转运、外流和排泄。LXR属于配体激活细胞受体,同时也是潜在的药物靶点,通过对LXR通路的操纵将有助于他汀类药物作用的发挥,而LXR配体已经用于动脉粥样硬化和高脂血症的早期临床试验中。同时,针对LXR及其靶向基因的研究为治疗以脂质代谢为核心的疾病(包括动脉粥样硬化和阿尔茨海默病)治疗提供了可能。 | 张静波 赵磊 岳亮 刘海啸 李霞 王伯栋 屈延 | 2016 | 中华临床医师杂志(电子版)2016，10，12： | 0 |
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