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		题名	作者	年代	出处	被引量
	1	Hepatoprotective properties of oleanolic and ursolic acids in anti-tubercular drug-induced liver damage显示文摘Objective:To estimate to what extent the mixture of ursolic acid and oleanolic acid,in addition to the antitubercular standard regime,affects the hepatotoxicity profile.Methods:Liver injury was induced in male BALB/c mice by administering,per os and daily for 11 weeks,a combination of anti-Tubercular(anti-TB) agents Rifampicin(10 mg/kg),Isoniazid(10 mg/kg),and Pyrazinamide(30 mg/kg).The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period(11 weeks).Biochemical and hematological analysis was supplemented by liver histological examination.Results:Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB drugs.Conclusions:The triterpene mixture is able to prevent the steatosis induced by the anti-TB drugs.	Gabriel A.Gutiérrez-Rebolledo Georgina A.Siordia-Reyes Mariana Meckes-Fischer Adelina Jiménez-Arellanes	2016	Asian Pacific Journal of Tropical Medicine2016，9，7：	10

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