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| 1 | 淋巴结微转移检测对结直肠癌病理分期的影响显示文摘目的分析淋巴结微转移对结直肠癌患者病理分期的影响。方法采用2003年3月至2008年10月间行手术切除的60例结直癌患者,对990枚淋巴结进行常规HE染色和CK20免疫组化微转移的检测,并对结果进行统计学分析。结果应用HE染色法淋巴结转移检出率27.2%(269/990),CK20免疫组化淋巴转移检测率为37.2%(368/990),两者比较有显著性差异(P<0.05)。99枚淋巴结检出有微转移,11例TNM分期提高,HE染色重新分期率为18.3%(11/60)。结论 CK20免疫组化的检测可以显著提高淋巴结转移的检出率,有助于更准确地进行结直肠癌的临床病理分期。 | 李弘 | 2015 | 世界最新医学信息文摘2015，15，46： | 1 |
| 2 | Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma显示文摘AIM: To evaluate whether serum and tumor indoleamine 2,3-dioxygenase activities can predict lymphatic invasion(LI) or lymph node metastasis in colorectal carcinoma.METHODS: The study group consisted of 44 colorectal carcinoma patients. The patients were re-grouped according to the presence or absence of LI and lymph node metastasis. Forty-three cancer-free subjects without any metabolic disturbances were included into the control group. Serum neopterin was measured by enzyme linked immunosorbent assay. Urinary neopterin and biopterin, serum tryptophan(Trp) and kynurenine(Kyn) concentrations of all patients were determined by high performance liquid chromatography. Kyn/Trp was calculated and its correlation with serum neopterin was determined to estimate the serum indoleamine 2,3-dioxygenase activity. Tissue sections from the studied tumors were re-examined histopathologicallyand were stained by immunohistochemistry with indoleamine-2,3-dioxygenase antibodies.RESULTS: Neither serum nor urinary neopterin was significantly different between the patient and control groups(both p > 0.05). However, colorectal carcinoma patients showed a significant positive correlation between the serum neopterin levels and Kyn/Trp(r = 0.450, p < 0.01). Urinary biopterin was significantly higher in cancer cases(p < 0.05). Serum Kyn/Trp was significantly higher in colorectal carcinoma patients(p < 0.01). Lymphatic invasion was present in 23 of 44 patients, of which only 12 patients had lymph node metastasis. Eleven patients with LI had no lymph node metastasis. Indoleamine-2,3-dioxygenase intensity score was significantly higher in LI positive cancer group(44.56% ± 6.11%) than negative colorectal cancer patients(24.04% ± 6.90%),(p < 0.05). Indoleamine 2,3-dioxygenase expression correlated both with the presence of LI and lymph node metastasis(p < 0.01 and p < 0.05, respectively). A significant difference between the accuracy of diagnosis by using either total indoleamine-2,3-dioxygenase immunostaining score or of lymph node metastasis was found during the evaluation of cancer patients.CONCLUSION: Indoleamine-2,3-dioxygenase expression may predict the presence of unrecognized LI and lymph node metastasis and may be included in the histopathological evaluation of colorectal carcinoma cases. | Atilla Engin Ipek Isik Gonul Ayse Basak Engin Ahmet Karamercan Aylin Sepici Dincel Ayse Dursun | 2016 | World Journal of Gastroenterology2016，22，13： | 1 |
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