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| 1 | 中西医结合治疗恶性肿瘤胸腔积液62例疗效观察显示文摘目的了解恶性肿瘤胸腔积液患者应用中西医结合方案进行治疗的临床疗效。方法随机抽取本院2012年1月-2014年1月收治应用中西医结合方案治疗的恶性肿瘤胸腔积液患者62例,另随机选取本院同期单纯接受西医方案治疗的恶性肿瘤胸腔积液患者50例。对比2组患者临床治疗效果及不良反应事件情况。结果观察组患者治疗后总有效率为83.9%,明显优于对照组患者总有效率56.0%,差异有统计学意义(P<0.05);2组患者治疗过程中均未发现存在严重毒副反应,差异无统计学意义(P>0.05)。结论对恶性肿瘤胸腔积液患者在常规西医方案基础上联合中医治疗,能够取得令人满意的临床疗效,且可提升患者生活质量,以积极的心态配合原发病治疗,值得临床普及和推广。 | 杨奇伟 | 2015 | 世界最新医学信息文摘2015，15，3： | 3 |
| 2 | Mechanical dyssynchrony and deformation imaging in patients with functional mitral regurgitation显示文摘Chronic functional mitral regurgitation(FMR) is a frequent finding of ischemic heart disease and dilated cardiomyopathy(DCM), associated with unfavourable prognosis. Several pathophysiologic mechanisms are involved in FMR, such as annular dilatation and dysfunction, left ventricle(LV) remodeling, dysfunction and dyssynchrony, papillary muscles displacement and dyssynchrony. The best therapeutic choice for FMR is still debated. When optimal medical treatment has already been set, a further option for cardiac resynchronization therapy(CRT) and/or surgical correction should be considered. CRT is able to contrast most of the pathophysiologic determinants of FMR by minimizing LV dyssynchrony through different mechanisms: Increasing closing forces, reducing tethering forces, reshaping annular geometry and function, correcting diastolic MR. Deformation imaging in terms of two-dimensional speckle tracking has been validated for LV dyssynchrony assessment. Radial speckle tracking and three-dimensional strain analysis appear to be the best methods to quantify intraventricular delay and to predict CRT-responders. Speckle-tracking echocardiography in patients with mitral valve regurgitation has been usually proposed for the assessment of LV and left atrial function. However it has also revealed a fundamental role of intraventricular dyssynchrony in determining FMR especially in DCM, rather than in ischemic cardiomyopathy in which MR severity seems to be more related to mitral valve deformation indexes. Furthermore speckle tracking allows the assessment of papillary muscle dyssynchrony. Therefore this technique can help to identify optimal candidates to CRT that will probably demonstrate a reduction in FMR degree and thus will experience a better outcome. | Isabella Rosa Claudia Marini Stefano Stella Francesco Ancona Marco Spartera Alberto Margonato Eustachio Agricola | 2016 | World Journal of Cardiology2016，8，2： | 2 |
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