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1Diagnostic and prognostic value of circulating micro RNAs in heart failure with preserved and reduced ejection fraction显示文摘micro RNAs(mi RNAs) are powerful regulators of posttranscriptional gene expression and play an important role in pathophysiological processes. Circulating mi RNAs can be quantified in body liquids and are promising biomarkers in numerous diseases. In cardiovascular disease mi RNAs have been proven to be reliable diagnostic biomarkers for different disease entities. In cardiac fibrosis(CF) and heart failure(HF) dysregulated circulating mi RNAs have been identified,indicating their promising applicability as diagnostic biomarkers. Some mi RNAs were successfully tested in risk stratification of HF implementing their potential use as prognostic biomarkers. In this respect mi RNAs might soon be implemented in diagnostic clinical routine. In the young field of mi RNA based research advances have been made in identifying mi RNAs as potential targets for the treatment of experimental CF and HF. Promising study results suggest their potential future application as therapeutic agents in treatment of cardiovascular disease. This article summarizes the current state of the various aspects of mi RNA research in the field of CF and HF with reduced ejection fraction as well as preserved ejection fraction. The review provides an overview of the application of circulating mi RNAs as biomarkers in CF and HF and current approaches to therapeutically utilize mi RNAs in this field of cardiovascular disease.Christian Schulte Dirk Westermann Stefan Blankenberg Tanja Zeller 2015World Journal of Cardiology2015,7,12:11
2miRNA与颈动脉狭窄的研究进展显示文摘颈动脉是将血液从心脏输送到头颈及面部的大血管,是颅脑的主要供血血管之一。动脉粥样硬化、颈动脉夹层及与自身免疫、发育、炎症有关的血管等多种原因可以导致颈动脉狭窄。不同病因导致的颈动脉狭窄及临床表现亦不同。本文探讨miRNA在颈动脉狭窄发生、发展过程中的作用过程及机理,对miRNA与颈动脉狭窄的有关研究进行综述。范星 周翔宇 2016现代临床医学2016,42,3:1
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